CAJ | 학술논문

目的：评估难治性颞叶癫痫术后患者的生活质量。方法：随访行手术治疗的难治性颞叶癫痫患者34例，分别于术前1月、术后6月、术后12月应用癫痫患者生活质量量表-31（QOLIE-31）中文版对患者生活质量进行评估；术后疗效根据 Engle 分级标准分为2组：满意组（EngleⅠ和Ⅱ级）和不满意组（EngleⅢ和Ⅳ级），比较2组生活质量。结果：术后6月随访，疗效满意23例（满意组），不满意11例（不满意组），满意组术后生活质量各方面均明显改善（P＜0.05），且在发作担忧、情感幸福、社会功能和总体生活质量方面改善优于不满意组（P＜0.05）；不满意组术后生活质量也较术前改善（P＜0.05），药物副作用差异无统计学意义（P=0.255）。术后12月随访，疗效满意27例（满意组），不满意 7例（不满意组），不满意组患者生活质量术后保持稳定，满意组生活质量仍明显改善，且各方面改善程度均较不满意组明显（P＜0.05）。结论：难治性颞叶癫痫手术可以改善术后早期的生活质量，生活质量的持续改善则与手术疗效密切相关。
목적：평고난치성섭협전간술후환자적생활질량。방법：수방행수술치료적난치성섭협전간환자34례，분별우술전1월、술후6월、술후12월응용전간환자생활질량량표-31（QOLIE-31）중문판대환자생활질량진행평고；술후료효근거 Engle 분급표준분위2조：만의조（EngleⅠ화Ⅱ급）화불만의조（EngleⅢ화Ⅳ급），비교2조생활질량。결과：술후6월수방，료효만의23례（만의조），불만의11례（불만의조），만의조술후생활질량각방면균명현개선（P＜0.05），차재발작담우、정감행복、사회공능화총체생활질량방면개선우우불만의조（P＜0.05）；불만의조술후생활질량야교술전개선（P＜0.05），약물부작용차이무통계학의의（P=0.255）。술후12월수방，료효만의27례（만의조），불만의 7례（불만의조），불만의조환자생활질량술후보지은정，만의조생활질량잉명현개선，차각방면개선정도균교불만의조명현（P＜0.05）。결론：난치성섭협전간수술가이개선술후조기적생활질량，생활질량적지속개선칙여수술료효밀절상관。
Objective: To evaluate the life quality of intractable temporal lobe epilepsy (TLE) patients after the surgery. Methods: Thirty-four intractable TLE patients undergoing epilepsy surgery were enrolled. Quality of life (QOL) was measured by the Quality of Life in Epilepsy Inventory-31 (QOLIE-31) before surgery, 6 months, and 12 months after surgery. Seizure outcome was assessed using Engle grading. Patients were divided into two groups according to surgery outcome: good outcome group (EngleⅠandⅡ) and poor outcome group (EngleⅢand Ⅳ). Results: At the 6-month follow-up, there was significant improvement in all the domains of QOLIE-31 in the good outcome group (23 cases) after surgery (P<0.05). QOL improvement was seen in all the domains in the poor outcome group (11 cases) except medication effects (P=0.255). At the 12-month follow-up, QOL continued to improve in the good outcome group (27 cases) and stabilized in the poor outcome group (7 cases). QOL was significantly better in the good outcome group than that in the poor outcome group (P<0.05). Conclusion: After temporal resection, QOL improves in the good outcome group while QOL in the poor outcome group stabilizes. These results may be useful in pre-surgical counseling and identifying patients at risk for poor psychosocial outcome following surgery.