中华临床医师杂志（电子版）
中華臨床醫師雜誌（電子版）
중화림상의사잡지（전자판）
CHINESE JOURNAL OF CLINICIANS(ELECTRONIC VERSION)
2015年
8期
1372-1376
,共5页
李文标%唐录英%邓欢%湛海伦%周祥福
李文標%唐錄英%鄧歡%湛海倫%週祥福
리문표%당록영%산환%담해륜%주상복
鱼腥草%膀胱炎,非细菌性%大鼠,Sprague-Dawley%膀胱灌注
魚腥草%膀胱炎,非細菌性%大鼠,Sprague-Dawley%膀胱灌註
어성초%방광염,비세균성%대서,Sprague-Dawley%방광관주
HOUTTUYNIA CORDATA%Cystitis,nonbacterial%Rats,Sprague-Dawley%Intravesical
目的：探讨鱼腥草提取液膀胱灌注治疗非细菌性膀胱炎的疗效及其作用机制。方法30只成年 SD 雌性大鼠随机平均分为三组，对照组和治疗组采用环磷酰胺腹腔注射构建非细菌性膀胱炎模型，空白组腹腔注射等体积生理盐水；建模成功后治疗组行鱼腥草提取液（2 g/ml）膀胱灌注治疗，每天1次，持续1周，空白组及对照组采用等体积生理盐水膀胱灌注处理；治疗完成后，分析比较各组大鼠尿频、疼痛、尿动力学参数、膀胱湿重、病理炎症程度、膀胱组织炎性因子（IL-6、IL-8、TNF-α）浓度等指标。结果与对照组相比，治疗组尿频次数明显降低（P＜0.05），疼痛阈值升高（P＜0.01），尿动力学参数中排尿间隔、膀胱容量、膀胱顺应性指标明显改善（均 P＜0.01），膀胱湿重（P＜0.01）及病理炎症等级（P＜0.05）降低，膀胱匀浆炎性因子浓度下降（P＜0.01）。结论鱼腥草提取液膀胱灌注治疗能有效改善非细菌性膀胱炎的炎症和尿频尿急及疼痛症状。
目的：探討魚腥草提取液膀胱灌註治療非細菌性膀胱炎的療效及其作用機製。方法30隻成年 SD 雌性大鼠隨機平均分為三組，對照組和治療組採用環燐酰胺腹腔註射構建非細菌性膀胱炎模型，空白組腹腔註射等體積生理鹽水；建模成功後治療組行魚腥草提取液（2 g/ml）膀胱灌註治療，每天1次，持續1週，空白組及對照組採用等體積生理鹽水膀胱灌註處理；治療完成後，分析比較各組大鼠尿頻、疼痛、尿動力學參數、膀胱濕重、病理炎癥程度、膀胱組織炎性因子（IL-6、IL-8、TNF-α）濃度等指標。結果與對照組相比，治療組尿頻次數明顯降低（P＜0.05），疼痛閾值升高（P＜0.01），尿動力學參數中排尿間隔、膀胱容量、膀胱順應性指標明顯改善（均 P＜0.01），膀胱濕重（P＜0.01）及病理炎癥等級（P＜0.05）降低，膀胱勻漿炎性因子濃度下降（P＜0.01）。結論魚腥草提取液膀胱灌註治療能有效改善非細菌性膀胱炎的炎癥和尿頻尿急及疼痛癥狀。
목적：탐토어성초제취액방광관주치료비세균성방광염적료효급기작용궤제。방법30지성년 SD 자성대서수궤평균분위삼조，대조조화치료조채용배린선알복강주사구건비세균성방광염모형，공백조복강주사등체적생리염수；건모성공후치료조행어성초제취액（2 g/ml）방광관주치료，매천1차，지속1주，공백조급대조조채용등체적생리염수방광관주처리；치료완성후，분석비교각조대서뇨빈、동통、뇨동역학삼수、방광습중、병리염증정도、방광조직염성인자（IL-6、IL-8、TNF-α）농도등지표。결과여대조조상비，치료조뇨빈차수명현강저（P＜0.05），동통역치승고（P＜0.01），뇨동역학삼수중배뇨간격、방광용량、방광순응성지표명현개선（균 P＜0.01），방광습중（P＜0.01）급병리염증등급（P＜0.05）강저，방광균장염성인자농도하강（P＜0.01）。결론어성초제취액방광관주치료능유효개선비세균성방광염적염증화뇨빈뇨급급동통증상。
Objective To investigate the efficacy of intravesical Houttuynia cordata extract in rats with nonbacterial cystitis induced by cyclophosphamide. Methods Total 30 adult female rats were randomly divided into three groups. Non-bacteria cystitis was induced by cyclophosphamide in treated group and control group and then treated with Houttuynia cordata extract (2 g/ml, once per day for one week) or volume-match Normal Saline (NS). Subsequently, urinary frequency, nociceptive behaviors, cystometry parameters, bladder weight, histological changes, and cytokine (IL-6, IL-8, TNF-α) concentration were evaluated and compared among three groups. Results Compared with the control group, lighter bladder weight (P<0.01), lower cytokine concentration (all P<0.01) and inflammation grade (P<0.05), less urinary voids (P<0.05), higher nociceptive threshold (P<0.01), longer intercontraction intervals (P<0.01), bigger bladder capacity (P<0.01) and better bladder compliance (P<0.01) were detected in treated group. Conclusion Intravesical Houttuynia cordata extract can improve symptoms of nonbacterial cystitis through anti-inflammatory effect, and may be an potentially valuable treatment for bladder pain syndrome/interstitial cystitis.
