中华临床医师杂志（电子版）
中華臨床醫師雜誌（電子版）
중화림상의사잡지（전자판）
CHINESE JOURNAL OF CLINICIANS(ELECTRONIC VERSION)
2015年
8期
1441-1443
,共3页
二肽基肽酶Ⅳ抑制剂%抗炎作用
二肽基肽酶Ⅳ抑製劑%抗炎作用
이태기태매Ⅳ억제제%항염작용
Dipeptidyl-peptidase Ⅳ inhibitors%Anti-inflammation
近年来，研究发现多种慢性疾病与非特异性炎症密切相关，CD26/二肽基肽酶-4（DPP-4）参与非特异性炎症过程。临床上使用的一类新型口服降糖药物，DPP-4抑制剂除促进胰岛素分泌，抑制胰高血糖素释放等多种机制控制血糖之外，还存在调节炎症反应的作用，为多种慢性非特异性炎症疾病的治疗提供新思路。本文就其抗炎作用作一简要综述。
近年來，研究髮現多種慢性疾病與非特異性炎癥密切相關，CD26/二肽基肽酶-4（DPP-4）參與非特異性炎癥過程。臨床上使用的一類新型口服降糖藥物，DPP-4抑製劑除促進胰島素分泌，抑製胰高血糖素釋放等多種機製控製血糖之外，還存在調節炎癥反應的作用，為多種慢性非特異性炎癥疾病的治療提供新思路。本文就其抗炎作用作一簡要綜述。
근년래，연구발현다충만성질병여비특이성염증밀절상관，CD26/이태기태매-4（DPP-4）삼여비특이성염증과정。림상상사용적일류신형구복강당약물，DPP-4억제제제촉진이도소분비，억제이고혈당소석방등다충궤제공제혈당지외，환존재조절염증반응적작용，위다충만성비특이성염증질병적치료제공신사로。본문취기항염작용작일간요종술。
In recent years, studies have found that a variety of chronic diseases are closely associated with nonspecific inflammation, CD26/Dipeptidyl peptidase-4 (DPP-4) involved in nonspecific inflammatory process. DPP-4 inhibitors are a new class of antidiabetic agents that effectively reduce blood glucose by stimulating insulin secretion from β-cells and inhibiting glucagon release. In addition, DPP-4 inhibitors may regulate the inflammatory response, which provide new insights into the treatment of various chronic nonspecific inflammatory diseases. This article reviewed the anti-inflammatory effect of DPP-4 inhibitors.
