CAJ | 학술논문

目的：观察补肾疏肝法治疗雄性激素水平正常男性更年期综合征(PADAM)的临床疗效。方法96例雄激素水平正常男性更年期综合征患者按就诊顺序随机分为观察组和对照组各48例，观察组用补肾疏肝法治疗，服用六味地黄汤合逍遥汤加减内服，每日1剂；对照组服用舍曲林50 mg/次，2次/日，谷维素20 mg/次，3次/日，2组均以3月为1疗程。观察治疗前后PADAM评分及性激素结合蛋白（SHBG）变化情况。结果观察组在PADAM各症状评分变化上优于对照组（P＜0.05）；与治疗前比较，观察组血清T水平升高、性激素结合蛋白水平降低，差异有统计学意义（P＜0.05）。结论补肾疏肝法可能通过增加血清中非SHBG结合睾酮水平发挥治疗作用，缓解临床症状，有效治疗男性更年期综合征。
목적：관찰보신소간법치료웅성격소수평정상남성경년기종합정(PADAM)적림상료효。방법96례웅격소수평정상남성경년기종합정환자안취진순서수궤분위관찰조화대조조각48례，관찰조용보신소간법치료，복용륙미지황탕합소요탕가감내복，매일1제；대조조복용사곡림50 mg/차，2차/일，곡유소20 mg/차，3차/일，2조균이3월위1료정。관찰치료전후PADAM평분급성격소결합단백（SHBG）변화정황。결과관찰조재PADAM각증상평분변화상우우대조조（P＜0.05）；여치료전비교，관찰조혈청T수평승고、성격소결합단백수평강저，차이유통계학의의（P＜0.05）。결론보신소간법가능통과증가혈청중비SHBG결합고동수평발휘치료작용，완해림상증상，유효치료남성경년기종합정。
Objective To observation the clinical efficacy of Bush en Shugan method on the treatment of the male climacteric syndrome (PADAM) in normal androgen levels. Methods 96 patients with the male climacteric syndrome in normal androgen levels were randomly divided into two groups. The observation group of 48 cases was treated by Bushen Shugan method with Liuwei Dihuang decoction and Xiaoyao decoction, and one dose each day. The control group of 48 cases took orally oryzanol with 50 mg twice a day and sertraline with 20 mg three times a day. The course of treatment was 3 months. The PADAM score and sex hormone binding globulin ( SHBG) were tested and analyzed before and after treatment. Results Changes of each symptom of PADAM score of the observation group were better than those of the control group ( P<0.05) . After treatment, the serum T level elevated and the SHBG levels declined, there was statistically significant ( P<0.05) . Conclusion The Bushen Shugan method took effect by increasing the level of non‐SHBG binding testosterone in serum, alleviated clinical symptoms and was effective in treating male climacteric syndrome in normal androgen levels.