CAJ | 학술논문

目的：应用微栓子信号（ MES）监测评估抗血小板聚集药和他汀类药物联用治疗急性缺血性脑卒中的疗效。方法62例急性缺血性脑卒中患者随机分为两组：两联治疗组（30例，采用氯比格雷加阿司匹林治疗）和瑞舒伐他汀组（32例，采用氯比格雷、阿司匹林及瑞舒伐他汀治疗）。分别在治疗前及治疗后第3 d、第7 d和第14 d采用TCD监测MES。比较两组MES监测结果。结果与治疗前相比，两组治疗后第3 d、第7 d和第14 d的MES数量均明显下降（均P＜0．05）。治疗后第3 d、第7 d和第14 d，瑞舒伐他汀组MES数量较两联治疗组明显下降（均P＜0．05）。瑞舒伐他汀组治疗后第3 d、第7 d和第14 d的MES下降率均明显高于两联治疗组（均P＜0．05）。结论两联抗血小板聚集药联用他汀类药物治疗急性缺血性脑卒中相较于单用两联抗血小板治疗可以取得更好的疗效。
목적：응용미전자신호（ MES）감측평고항혈소판취집약화타정류약물련용치료급성결혈성뇌졸중적료효。방법62례급성결혈성뇌졸중환자수궤분위량조：량련치료조（30례，채용록비격뢰가아사필림치료）화서서벌타정조（32례，채용록비격뢰、아사필림급서서벌타정치료）。분별재치료전급치료후제3 d、제7 d화제14 d채용TCD감측MES。비교량조MES감측결과。결과여치료전상비，량조치료후제3 d、제7 d화제14 d적MES수량균명현하강（균P＜0．05）。치료후제3 d、제7 d화제14 d，서서벌타정조MES수량교량련치료조명현하강（균P＜0．05）。서서벌타정조치료후제3 d、제7 d화제14 d적MES하강솔균명현고우량련치료조（균P＜0．05）。결론량련항혈소판취집약련용타정류약물치료급성결혈성뇌졸중상교우단용량련항혈소판치료가이취득경호적료효。
Objective To study the monitoring of microembolic signal ( MES) in assessing the curative effect of platelet aggregation drugs combined with statins on treating acute ischemic stroke.Methods Sixty-two patients with acute ischemic stroke were randomly divided into two groups: two couplet treatment group (30 cases, treated with Clopidogrel and Aspirin) and Rosuvastatin group (32 cases, treated with Clopidogrel, Aspirin and Rosuvastatin). The MES was assessed by TCD before treatment and at 3 d, 7 d and 14 d after treatment, respectively.And the results of MES assessment were compared between the two groups.Results Compared with before treatment, the MES numbers of the two groups at 3 d, 7 d and 14 d after treatment were significantly decreased (all P<0.05).At 3 d, 7 d and 14 d after treatment, the MES numbers of Rosuvastatin group were significantly lower than those in the two couplet treatment group ( all P<0.05) .The drop rate of MES in the Rosuvastatin group at 3 d, 7 d and 14 d after treatment were significantly higher than those in the two couplet treatment group (all P<0.05).Conclusion The curative effect of two couplet treatment of platelet aggregation drugs combined with statins on treating acuteischemic stroke is better than only two couplet treatment.