CAJ | 학술논문

目的：考察热毒宁注射液与两种常用溶媒配伍后制剂中绿原酸、新绿原酸、隐绿原酸、咖啡酸、栀子苷、断氧化马钱子苷、异绿原酸A、异绿原酸B、异绿原酸C等9种成分的稳定性，为临床用药提供实验依据。方法：将热毒宁注射液分别与5%葡萄糖注射液和0.9%氯化钠注射液按50∶250的比例配伍，考察0~6 h内配伍药液中9种成分含量变化情况。结果与结论：热毒宁注射液与5%葡萄糖注射液和0.9%氯化钠注射液配伍6 h内，其中9种成分均稳定。
목적：고찰열독저주사액여량충상용용매배오후제제중록원산、신록원산、은록원산、가배산、치자감、단양화마전자감、이록원산A、이록원산B、이록원산C등9충성분적은정성，위림상용약제공실험의거。방법：장열독저주사액분별여5%포도당주사액화0.9%록화납주사액안50∶250적비례배오，고찰0~6 h내배오약액중9충성분함량변화정황。결과여결론：열독저주사액여5%포도당주사액화0.9%록화납주사액배오6 h내，기중9충성분균은정。
Objective: To investigate the compatible stability of chlorogenic acid, neochlorogenic acid, cryptochlorogenic acid, cafferic acid, geniposide, secoxyloganin, isochlorogenic acid A, isochlorogenic acid B and isochlorogenic acid C in Reduning Injection mixed with two solvents, to provide an experimental basis for clinical medicine. Methods: The changes of the nine components in Reduning injection combined with 5% glucose injection or 0.9% sodium chloride injection respectively (Reduning injection : solvent=50:250) were determined by HPLC. Results and Conclusion: The 9 components were stable in 6 h after combin-ing Reduning injection and 5% glucose injection or 0.9% sodium chloride injection.