CAJ | 학술논문

目的：探讨C反应蛋白（ CRP）1059G／C基因多态性与脑梗死患者颈动脉粥样硬化的关系。方法对126例急性脑梗死患者进行颈动脉超声检测，根据双侧颈动脉内膜－中层厚度（ CIMT）分为颈动脉粥样硬化组和无颈动脉粥样硬化组。采用PCR法检测CRP基因1059G／C多态性。对结果进行组间比较并分析。结果颈动脉超声检测结果显示，颈动脉粥样硬化组71例（56．3％），非颈动脉粥样硬化组55例（43．7％）。颈动脉粥样硬化组CRP 1059G／C基因G／G基因型比例、G等位基因频率明显高于非颈动脉粥样硬化组（均P＜0．05）。颈动脉粥样硬化组CRP 1059G／C基因G／C基因型比例、C等位基因频率明显低于非颈动脉粥样硬化组（均P＜0．05）。结论 CRP 1059G／C基因多态性可能与脑梗死患者动脉粥样硬化有关。 CRP 1059G／C基因G／G基因型可能是影响脑梗死患者动脉粥样硬化的进程的危险因素之一。
목적：탐토C반응단백（ CRP）1059G／C기인다태성여뇌경사환자경동맥죽양경화적관계。방법대126례급성뇌경사환자진행경동맥초성검측，근거쌍측경동맥내막－중층후도（ CIMT）분위경동맥죽양경화조화무경동맥죽양경화조。채용PCR법검측CRP기인1059G／C다태성。대결과진행조간비교병분석。결과경동맥초성검측결과현시，경동맥죽양경화조71례（56．3％），비경동맥죽양경화조55례（43．7％）。경동맥죽양경화조CRP 1059G／C기인G／G기인형비례、G등위기인빈솔명현고우비경동맥죽양경화조（균P＜0．05）。경동맥죽양경화조CRP 1059G／C기인G／C기인형비례、C등위기인빈솔명현저우비경동맥죽양경화조（균P＜0．05）。결론 CRP 1059G／C기인다태성가능여뇌경사환자동맥죽양경화유관。 CRP 1059G／C기인G／G기인형가능시영향뇌경사환자동맥죽양경화적진정적위험인소지일。
Objective To investigate the relationship between C reaction protein ( CRP ) 1059G/C gene polymorphism and carotid artery atherosclerosis in patients with cerebral infarction.Methods Carotid ultrasound detection was used to detect 126 patients with cerebral infarction.According to the bilateral carotid intima-middle thickness ( CIMT ) , these patients were divided into carotid artery atherosclerosis group and no carotid artery atherosclerosis group.PCR method was used to detect the CRP 1059G/C gene polymorphism.The results were analyzed.Results Carotid ultrasound detection showed that 71 cases (56.3%) in carotid artery atherosclerosis group and 55 cases (43.7%) in no carotid artery atherosclerosis group.The G/G genotype frequency and G allele frequency of CRP 1059G/C in carotid artery atherosclerosis group were significantly higher than those in no carotid artery atherosclerosis group (all P<0.05).The G/C genotype frequency and C allele frequency of CRP 1059G/C in carotid artery atherosclerosis group were significantly lower than those in no carotid artery atherosclerosis group ( all P<0.05) .Conclusion CRP 1059G/C gene polymorphism may be related with carotid artery atherosclerosis in patients with cerebral infarction.The G/G genotype of CRP 1059G/C may be one of the risk factors of carotid artery atherosclerosis in patients with cerebral infarction.