CAJ | 학술논문

脑缺血损伤是十分复杂的病理过程，伴随着一系列的炎症、氧化应激等反应。在脑缺血损伤中，细胞因子发挥了重要作用。 JAK/STAT信号转导通路与脑缺血密切相关，是调节脑缺血后细胞因子反应的关键通路，能够调节基因转录模式的变化，进而引起细胞存活或死亡而影响脑缺血损伤。因此，了解并掌握JAK/STAT通路与脑缺血损伤之间的关系具有重要意义，能为抗脑缺血药物研究提供另一种思路。本文对JAK/STAT通路、JAK/STAT通路与脑缺血损伤的关系以及与JAK/STAT通路相关的抗脑缺血药物研究进行综述，为抗脑缺血药物的研发提供一定的参考。
뇌결혈손상시십분복잡적병리과정，반수착일계렬적염증、양화응격등반응。재뇌결혈손상중，세포인자발휘료중요작용。 JAK/STAT신호전도통로여뇌결혈밀절상관，시조절뇌결혈후세포인자반응적관건통로，능구조절기인전록모식적변화，진이인기세포존활혹사망이영향뇌결혈손상。인차，료해병장악JAK/STAT통로여뇌결혈손상지간적관계구유중요의의，능위항뇌결혈약물연구제공령일충사로。본문대JAK/STAT통로、JAK/STAT통로여뇌결혈손상적관계이급여JAK/STAT통로상관적항뇌결혈약물연구진행종술，위항뇌결혈약물적연발제공일정적삼고。
Ischemic cerebral injury is a complex pathological process, which causes neuronal necrosis and generates in-flammations. Cytokines are major mediators of the inflammatory response after cerebral ischemia. JAK (Janus kinase)/STAT (signal transducer and activator of transcription) pathway plays a critical role in the intracellular responses to cytokines in is-chemic brain, which induces alterations in the pattern of gene transcription that are associated either with cell death or sur-vival. Therefore, it may provide another way to study the drugs of anti cerebral ischemia with JAK/STAT as the therapeutic target. This review introduces and summarizes the critical role of JAK/STAT pathway in cerebral ischemia injury, which may provide reference for the drug of anti cerebral ischemia in the future.