药学与临床研究
藥學與臨床研究
약학여림상연구
PHARMACEUTICAL AND CLINICAL RESEARCH
2015年
2期
160-163
,共4页
前列腺癌%PI3K%Akt%mTOR%靶向治疗
前列腺癌%PI3K%Akt%mTOR%靶嚮治療
전렬선암%PI3K%Akt%mTOR%파향치료
Prostate cancer%PI3K%Akt%mTOR%Rargeted therapy
前列腺癌是威胁中老年男性健康的常见肿瘤，成为男性癌症死因的第二位。 PI3K/Akt/mTOR信号通路能够通过维持细胞生存、抑制细胞凋亡、促进细胞周期运行及血管生成等促进前列腺癌病程发展。本文综合国内外文献，阐述PI3K/Akt/mTOR信号通路在前列腺癌发生发展中的作用以及和通路相关的药物治疗进展。
前列腺癌是威脅中老年男性健康的常見腫瘤，成為男性癌癥死因的第二位。 PI3K/Akt/mTOR信號通路能夠通過維持細胞生存、抑製細胞凋亡、促進細胞週期運行及血管生成等促進前列腺癌病程髮展。本文綜閤國內外文獻，闡述PI3K/Akt/mTOR信號通路在前列腺癌髮生髮展中的作用以及和通路相關的藥物治療進展。
전렬선암시위협중노년남성건강적상견종류，성위남성암증사인적제이위。 PI3K/Akt/mTOR신호통로능구통과유지세포생존、억제세포조망、촉진세포주기운행급혈관생성등촉진전렬선암병정발전。본문종합국내외문헌，천술PI3K/Akt/mTOR신호통로재전렬선암발생발전중적작용이급화통로상관적약물치료진전。
Prostate cancer is the most common cancer which threatens middle and old age men's health and is the second leading cause of cancer-related mortality in men. PI3K/Akt/mTOR signaling pathway promotes the progression of prostate cancer through maintaining cell survival, inhibiting cell apoptosis, accelerating cell cycle and angiogenesis. Here, we review the role of the PI3K/Akt/mTOR pathway in prostate cancer and discuss the potential use of pathway inhibitors in the evolving treatment landscape of prostate cancer.
