CAJ | 학술논문

目的：探讨异环磷酰胺化疗后出血性膀胱炎（HC）发生的相关因素。方法：对江苏省肿瘤医院2013年1月~2014年7月收治的使用含异环磷酰胺（IFO）方案进行化疗的患者资料进行了回顾性分析，采用Cox回归模型分析HC发生的相关危险因素。结果：104例使用含IFO方案化疗的患者中，HC发生率为14.4%（15/104）。Cox分析显示，性别（女性，P=0.045）、年龄（41~60岁，P=0.036）、IFO单次给药剂量（单次给药剂量>6.0 g，P<0.000）、有环磷酰胺用药史的（P=0.046）是HC发生的危险因素。结论：对具有这些危险因素的患者，常规的预防方案常常不能完全有效地避免HC的发生，因此，应当密切观察，可以采用增加美司钠的用量等措施，预防HC的发生。
목적：탐토이배린선알화료후출혈성방광염（HC）발생적상관인소。방법：대강소성종류의원2013년1월~2014년7월수치적사용함이배린선알（IFO）방안진행화료적환자자료진행료회고성분석，채용Cox회귀모형분석HC발생적상관위험인소。결과：104례사용함IFO방안화료적환자중，HC발생솔위14.4%（15/104）。Cox분석현시，성별（녀성，P=0.045）、년령（41~60세，P=0.036）、IFO단차급약제량（단차급약제량>6.0 g，P<0.000）、유배린선알용약사적（P=0.046）시HC발생적위험인소。결론：대구유저사위험인소적환자，상규적예방방안상상불능완전유효지피면HC적발생，인차，응당밀절관찰，가이채용증가미사납적용량등조시，예방HC적발생。
Objec tive: To analyze the risk fac-tors of ifosfamide (IFO) induced hemorrhagic cysti-tis (HC). Methods: The data of 104 patients treat-ed with chemotherapy regimens containing ifos-famide in Jiangsu Cancer Hospital from January 2013 to July 2014 were studied. A cox regression model was employed to analyze the clinical records of the total 104 cases respectively. Results: There were 15 of the 104 patients appeared HC (14.4%). Cox analysis showed that sex (female, P=0.045), age (41~60, P=0.036), single dose of IFO (single dose of IFO>6.0 g, P<0.000), medication history of cyclophosphamide (medication history of cyclophos-phamide is yes, P=0.046) were the risk factor for HC. Conclusions: Strengthening the observation, increasing the dose of mesna and other measures should be taken to avoid the occurrence of HC.