医学与哲学
醫學與哲學
의학여철학
MEDICINE AND PHILOSOPHY
2015年
8期
57-59
,共3页
宫颈上皮内瘤变%宫颈癌%光动力疗法%人乳头瘤病毒
宮頸上皮內瘤變%宮頸癌%光動力療法%人乳頭瘤病毒
궁경상피내류변%궁경암%광동력요법%인유두류병독
cervical intraepithelial neoplasia%uterine cervical neoplasia%photodynamic therapy%human papilloma virus
光动力疗法（PD T ）是一种新的微创治疗技术，近年来在治疗宫颈病变方面取得了较大的进步。本文根据国内外最新临床研究，分析PDT治疗宫颈病变的临床应用进展。PDT治疗宫颈上皮内瘤变（CIN）的效果与光敏剂的种类及给药途径、光照时间、CIN级别等有关，CIN的缓解率可达80％以上。PDT治疗早期宫颈癌的研究较少，但完全缓解率可达90％以上。PDT对人乳头瘤病毒（HPV）感染有一定的疗效，HPV清除率为53．4％～94．4％。PDT 主要的不良反应是皮肤光毒性。尽管目前的研究存在不足，但PD T治疗宫颈病变具有广阔的应用前景。
光動力療法（PD T ）是一種新的微創治療技術，近年來在治療宮頸病變方麵取得瞭較大的進步。本文根據國內外最新臨床研究，分析PDT治療宮頸病變的臨床應用進展。PDT治療宮頸上皮內瘤變（CIN）的效果與光敏劑的種類及給藥途徑、光照時間、CIN級彆等有關，CIN的緩解率可達80％以上。PDT治療早期宮頸癌的研究較少，但完全緩解率可達90％以上。PDT對人乳頭瘤病毒（HPV）感染有一定的療效，HPV清除率為53．4％～94．4％。PDT 主要的不良反應是皮膚光毒性。儘管目前的研究存在不足，但PD T治療宮頸病變具有廣闊的應用前景。
광동력요법（PD T ）시일충신적미창치료기술，근년래재치료궁경병변방면취득료교대적진보。본문근거국내외최신림상연구，분석PDT치료궁경병변적림상응용진전。PDT치료궁경상피내류변（CIN）적효과여광민제적충류급급약도경、광조시간、CIN급별등유관，CIN적완해솔가체80％이상。PDT치료조기궁경암적연구교소，단완전완해솔가체90％이상。PDT대인유두류병독（HPV）감염유일정적료효，HPV청제솔위53．4％～94．4％。PDT 주요적불량반응시피부광독성。진관목전적연구존재불족，단PD T치료궁경병변구유엄활적응용전경。
Photodynamic therapy (PDT ) ,as a new minimal invasive therapy ,has made great progress in uterine cervical lesions treatment in recent years .According to recent research at home and abroad ,we reviewed clinical application progress of PDT in cervical lesions treatment .The effect of PDT on cervical intraepithelial neoplasia (CIN) is related to photosensitizer and route of administration ,light duration and CIN grades .Remission rate of CIN after PDT was more than 80% .Complete remission rate of early cervical cancer was more than 90% ,though reserach were limited .PDT was also effective for HPV infection with HPV clerance ranging from 53 .4% to 94 .4% . The principal side effect of PDT was skin phototoxicity . PDT has potential application prospect in uterine cervical lesions treatment though current research has disadvantages .
