国际内分泌代谢杂志
國際內分泌代謝雜誌
국제내분비대사잡지
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2015年
2期
127-129
,共3页
刘琦%周赛君%孟振兴%于珮
劉琦%週賽君%孟振興%于珮
류기%주새군%맹진흥%우패
P2X7受体%糖尿病视网膜病变%细胞凋亡%炎症
P2X7受體%糖尿病視網膜病變%細胞凋亡%炎癥
P2X7수체%당뇨병시망막병변%세포조망%염증
P2X7 receptor%Diabetic retinopathy%Apoptosis%Inflammation
P2X7受体是一种重要的凋亡调控受体,是嘌呤受体家族中的一员,也是ATP活化的配体门控离子通道的调节者.它在中枢和外周神经系统中对介导兴奋性神经递质起重要作用.P2X7受体广泛表达于视网膜多种细胞表面.研究显示,P2X7受体在糖尿病视网膜病变中过度激活,参与糖尿病视网膜病变的发生及发展.一方面,P2X7受体过度激活所致的嘌呤血管毒性,可导致视网膜血流减少和血管功能的紊乱;另一方面,P2X7受体活化可导致大量炎性因子的产生,引起局部炎性细胞浸润,形成血管炎性微环境,构成糖尿病视网膜病变发生、发展的病理生理基础.
P2X7受體是一種重要的凋亡調控受體,是嘌呤受體傢族中的一員,也是ATP活化的配體門控離子通道的調節者.它在中樞和外週神經繫統中對介導興奮性神經遞質起重要作用.P2X7受體廣汎錶達于視網膜多種細胞錶麵.研究顯示,P2X7受體在糖尿病視網膜病變中過度激活,參與糖尿病視網膜病變的髮生及髮展.一方麵,P2X7受體過度激活所緻的嘌呤血管毒性,可導緻視網膜血流減少和血管功能的紊亂;另一方麵,P2X7受體活化可導緻大量炎性因子的產生,引起跼部炎性細胞浸潤,形成血管炎性微環境,構成糖尿病視網膜病變髮生、髮展的病理生理基礎.
P2X7수체시일충중요적조망조공수체,시표령수체가족중적일원,야시ATP활화적배체문공리자통도적조절자.타재중추화외주신경계통중대개도흥강성신경체질기중요작용.P2X7수체엄범표체우시망막다충세포표면.연구현시,P2X7수체재당뇨병시망막병변중과도격활,삼여당뇨병시망막병변적발생급발전.일방면,P2X7수체과도격활소치적표령혈관독성,가도치시망막혈류감소화혈관공능적문란;령일방면,P2X7수체활화가도치대량염성인자적산생,인기국부염성세포침윤,형성혈관염성미배경,구성당뇨병시망막병변발생、발전적병리생리기출.
P2X7 receptor,an important apoptosis regulatory receptor,is a member of the purinergic receptor family and a regulator of the ligand gated ion channel activated by ATP.P2X7 plays an important role in meditating excitatory neurotransmitter in the central and peripheral nervous system.The expression of P2X7 receptor has been demonstrated in most types of cells in the retina.Studies have shown that excessive activation of P2X7 receptor involves in the occurrence and development of diabetic retinopathy.In one hand,purinergic vasotoxicity caused by excessive activation of P2X7 receptor can lead to the reduction of retinal blood flow and vascular dysfunction.On the other hand,P2X7 receptor activation may result in the production of a large number of inflammatory cytokines,causing local inflammatory cell infiltration and the formation of vascular inflammatory microenvironment,which constitute the pathophysiological basis for the development of diabetic retinopathy.