CAJ | 학술논문

胰岛β细胞内质网中有大量新合成的胰岛素及胰岛素前体即胰岛素原,胰岛素原经过正确的处理转换为天然折叠单体形式即有活性的胰岛素原,后者经过剪切去除C肽而形成胰岛素,从而发挥生物学效应.未折叠或者错误折叠的胰岛素原则仍以非天然折叠多肽的形式存在于内质网中.任何原因导致的胰岛素原折叠率的改变均会导致胰岛素原稳态失衡,导致内质网应激和胰岛β细胞的功能改变.
이도β세포내질망중유대량신합성적이도소급이도소전체즉이도소원,이도소원경과정학적처리전환위천연절첩단체형식즉유활성적이도소원,후자경과전절거제C태이형성이도소,종이발휘생물학효응.미절첩혹자착오절첩적이도소원칙잉이비천연절첩다태적형식존재우내질망중.임하원인도치적이도소원절첩솔적개변균회도치이도소원은태실형,도치내질망응격화이도β세포적공능개변.
There is a large number of newly synthetic insulin and proinsulin in endoplasmic reticulum of islet [β cells.If correctly folded,proinsulin can be converted into native folded monomeric proinsulin with activity.Unfolded or misfolded non-native form of proinsulin will be preserved in the endoplasmic reticulum as the folded polypeptide.Changes of proinsulin folding rate caused by any reasons will result in the imbalance of proinsulin homeostasis,endoplasmic reticulum stress and islet [β cells dysfunction.