国际内分泌代谢杂志
國際內分泌代謝雜誌
국제내분비대사잡지
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2015年
2期
100-102,113
,共4页
脂蛋白脂酶%基因突变%高甘油三酯血症%糖尿病
脂蛋白脂酶%基因突變%高甘油三酯血癥%糖尿病
지단백지매%기인돌변%고감유삼지혈증%당뇨병
Lipoprotein lipase%Gene mutation%Hypertriglyceridemia%Diabetes mellitus
脂蛋白脂酶是甘油三酯代谢的关键酶.脂蛋白脂酶基因突变将导致其结构和功能变异,通过影响其活性和含量而影响其脂解功能,进而影响全身脂质代谢和分布.研究发现,脂蛋白脂酶基因突变与高甘油三酯血症、肥胖、糖尿病等内分泌代谢疾病的发生、发展密切相关.脂蛋白脂酶基因可能成为上述疾病早期干预和治疗的新方向.
脂蛋白脂酶是甘油三酯代謝的關鍵酶.脂蛋白脂酶基因突變將導緻其結構和功能變異,通過影響其活性和含量而影響其脂解功能,進而影響全身脂質代謝和分佈.研究髮現,脂蛋白脂酶基因突變與高甘油三酯血癥、肥胖、糖尿病等內分泌代謝疾病的髮生、髮展密切相關.脂蛋白脂酶基因可能成為上述疾病早期榦預和治療的新方嚮.
지단백지매시감유삼지대사적관건매.지단백지매기인돌변장도치기결구화공능변이,통과영향기활성화함량이영향기지해공능,진이영향전신지질대사화분포.연구발현,지단백지매기인돌변여고감유삼지혈증、비반、당뇨병등내분비대사질병적발생、발전밀절상관.지단백지매기인가능성위상술질병조기간예화치료적신방향.
Lipoprotein lipase is a key enzyme of triglycerides metabolism.Mutations will cause variations in the structure and function of lipoprotein lipase gene,affecting the lipolytic function by altering its activity and level,which further affects the whole body lipid metabolism and distribution.Recent studies have found that these mutations are associated with hypertriglyceridemia,obesity,diabetes mellitus and so on.Lipoprotein lipase may become a novel target for the early prevention and treatment of these diseases.
