国际内分泌代谢杂志
國際內分泌代謝雜誌
국제내분비대사잡지
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2015年
2期
84-87
,共4页
郑仁东%曹琳%刘克冕%褚晓秋%曹雯%孙洪平%刘超
鄭仁東%曹琳%劉剋冕%褚曉鞦%曹雯%孫洪平%劉超
정인동%조림%류극면%저효추%조문%손홍평%류초
糖尿病%肥胖%性腺功能减退症%男性%睾酮
糖尿病%肥胖%性腺功能減退癥%男性%睪酮
당뇨병%비반%성선공능감퇴증%남성%고동
Diabetes mellitus%Obesity%Hypogonadism%Male%Testosterone
目的 观察超重或肥胖的男性2型糖尿病患者性激素水平及胰岛素抵抗、糖脂代谢的变化.方法 选择男性2型糖尿病患者112例,根据体重指数分为体重正常组(50例)和超重或肥胖组(62例).所有患者测定血糖、血脂、胰岛素及性激素水平,包括睾酮、性激素结合球蛋白(SHBG)、孕激素、催乳素、黄体生成素、卵泡刺激素、雌二醇、脱氢表雄酮,并计算得出游离睾酮、生物活性睾酮.比较两组性激素水平、糖脂代谢及胰岛素抵抗相关指标的差异.结果 与体重正常组相比,超重或肥胖组空腹血糖、HbA1c、尿酸、空腹胰岛素和餐后胰岛素水平显著升高(f=-4.58～-2.35,P均＜0.05);总睾酮、SHBG水平显著降低(t=2.17,2.06,P均＜0.05).Pearson相关性分析发现,体重指数、腰围与总睾酮(r =-0.40,-0.41,P均＜0.01)、SHBG(r =-0.33,-0.42,P均＜0.01)呈显著负相关.总胆固醇和甘油三酯与总睾酮(r =-0.28,-0.24,P均=0.01)、SHBG(r =-0.27,-0.37,P均≤0.01)呈负相关;空腹胰岛素、餐后胰岛素、稳态模型评估-胰岛素抵抗指数(HOMA-IR)与总睾酮(r=-0.30-0.21,P均=0.01)、SHBG水平(r=-0.29-0.20,P均≤0.05)呈负相关.结论 超重或肥胖的男性2型糖尿病患者常存在性腺功能减退症,并与胰岛素抵抗和脂代谢异常密切相关.
目的 觀察超重或肥胖的男性2型糖尿病患者性激素水平及胰島素牴抗、糖脂代謝的變化.方法 選擇男性2型糖尿病患者112例,根據體重指數分為體重正常組(50例)和超重或肥胖組(62例).所有患者測定血糖、血脂、胰島素及性激素水平,包括睪酮、性激素結閤毬蛋白(SHBG)、孕激素、催乳素、黃體生成素、卵泡刺激素、雌二醇、脫氫錶雄酮,併計算得齣遊離睪酮、生物活性睪酮.比較兩組性激素水平、糖脂代謝及胰島素牴抗相關指標的差異.結果 與體重正常組相比,超重或肥胖組空腹血糖、HbA1c、尿痠、空腹胰島素和餐後胰島素水平顯著升高(f=-4.58～-2.35,P均＜0.05);總睪酮、SHBG水平顯著降低(t=2.17,2.06,P均＜0.05).Pearson相關性分析髮現,體重指數、腰圍與總睪酮(r =-0.40,-0.41,P均＜0.01)、SHBG(r =-0.33,-0.42,P均＜0.01)呈顯著負相關.總膽固醇和甘油三酯與總睪酮(r =-0.28,-0.24,P均=0.01)、SHBG(r =-0.27,-0.37,P均≤0.01)呈負相關;空腹胰島素、餐後胰島素、穩態模型評估-胰島素牴抗指數(HOMA-IR)與總睪酮(r=-0.30-0.21,P均=0.01)、SHBG水平(r=-0.29-0.20,P均≤0.05)呈負相關.結論 超重或肥胖的男性2型糖尿病患者常存在性腺功能減退癥,併與胰島素牴抗和脂代謝異常密切相關.
목적 관찰초중혹비반적남성2형당뇨병환자성격소수평급이도소저항、당지대사적변화.방법 선택남성2형당뇨병환자112례,근거체중지수분위체중정상조(50례)화초중혹비반조(62례).소유환자측정혈당、혈지、이도소급성격소수평,포괄고동、성격소결합구단백(SHBG)、잉격소、최유소、황체생성소、란포자격소、자이순、탈경표웅동,병계산득출유리고동、생물활성고동.비교량조성격소수평、당지대사급이도소저항상관지표적차이.결과 여체중정상조상비,초중혹비반조공복혈당、HbA1c、뇨산、공복이도소화찬후이도소수평현저승고(f=-4.58～-2.35,P균＜0.05);총고동、SHBG수평현저강저(t=2.17,2.06,P균＜0.05).Pearson상관성분석발현,체중지수、요위여총고동(r =-0.40,-0.41,P균＜0.01)、SHBG(r =-0.33,-0.42,P균＜0.01)정현저부상관.총담고순화감유삼지여총고동(r =-0.28,-0.24,P균=0.01)、SHBG(r =-0.27,-0.37,P균≤0.01)정부상관;공복이도소、찬후이도소、은태모형평고-이도소저항지수(HOMA-IR)여총고동(r=-0.30-0.21,P균=0.01)、SHBG수평(r=-0.29-0.20,P균≤0.05)정부상관.결론 초중혹비반적남성2형당뇨병환자상존재성선공능감퇴증,병여이도소저항화지대사이상밀절상관.
Objective To investigate the changes of sex hormone levels,insulin resistance,glucose and lipid metabolism in overweight or obese type 2 diabetic male patients.Methods A total of 112 type 2 diabetic male patients were enrolled and divided into normal weight group (n=50) and overweight or obese group (n=62) according to body mass index.Blood glucose,blood lipids,insulin,and sex hormones including testosterone,sex hormone binding globulin (SHBG),pregnendione,prolactin,luteinizing hormone,folliclestimulating hormone,estradiol,dehydroepiandrosterone were measured,and free testosterone and bioavailable testosterone were calculated.The correlations between sex hormone levels and glycolipid metabolism,insulin resistance related markers were analyzed.Results Compared with normal weight group,fasting blood glucose,HbA 1 c,uric acid,fasting insulin,postprandial insulin were significantly increased in overweight or obese group (t =-4.58--2.35,all P＜0.05); total testosterone and SHBG levels were significantly decreased (t =2.17,2.06,all P＜0.05) in overweight or obese group.Pearson correlation analysis found that body mass index,waist circumference were negatively correlated with total testosterone (r =-0.40,-0.41,all P＜0.01) and SHBG (r =-0.33,-0.42,all P＜0.01).Total cholesterol and triglycerides were negatively correlated with total testosterone (r =-0.28,-0.24,all P =0.01) and SHBG (r =-0.27,-0.37,all P≤0.01).Fasting insulin,postprandial insulin and homeostasis model assessment-insulin resistance were negatively correlated with total testosterone (r =-0.30--0.21,all P =0.01) and SHBG (r =-0.29--0.20,all P ≤ 0.05).Conclusions Hypogonadism is common in overweight or obese type 2 diabetic male patients,and is associated with insulin resistance and dyslipidemia.
