皖南医学院学报
皖南醫學院學報
환남의학원학보
ACTA ACADEMIAE MEDICINAE WANNAN
2015年
2期
182-184
,共3页
炎性肌纤维母细胞瘤%乳腺%临床病理特征
炎性肌纖維母細胞瘤%乳腺%臨床病理特徵
염성기섬유모세포류%유선%림상병리특정
inflammatory myofibroblastic tumor%breast%clinicopatholoical features
目的：探讨乳腺炎性肌纤维母细胞瘤的临床病理学特征、诊断和鉴别诊断等。方法：对2例乳腺炎性肌纤维母细胞瘤进行临床、病理形态以及免疫组化标记，并复习相关文献。结果：2例患者临床表现为乳房肿块伴有胀痛。大体上，肿瘤切面灰白、实性，可有黏液感。镜下，肿块边界清楚或者欠清，黏液或胶原背景下瘤细胞以梭形细胞为主，瘤细胞无明显异型性，核分裂象少见；间质血管丰富，见淋巴细胞、浆细胞等浸润。免疫组化梭形细胞vimentin （＋），SMA、Desmin和 ALK不同程度（＋），而CK、S-100、Myogenin、bcl-2和CD34均（－）。结论：乳腺炎性肌纤维母细胞瘤比较少见，形态多样，并缺乏特异性免疫标记，病理诊断有时较困难，应与一些梭形细胞肿瘤或病变鉴别。
目的：探討乳腺炎性肌纖維母細胞瘤的臨床病理學特徵、診斷和鑒彆診斷等。方法：對2例乳腺炎性肌纖維母細胞瘤進行臨床、病理形態以及免疫組化標記，併複習相關文獻。結果：2例患者臨床錶現為乳房腫塊伴有脹痛。大體上，腫瘤切麵灰白、實性，可有黏液感。鏡下，腫塊邊界清楚或者欠清，黏液或膠原揹景下瘤細胞以梭形細胞為主，瘤細胞無明顯異型性，覈分裂象少見；間質血管豐富，見淋巴細胞、漿細胞等浸潤。免疫組化梭形細胞vimentin （＋），SMA、Desmin和 ALK不同程度（＋），而CK、S-100、Myogenin、bcl-2和CD34均（－）。結論：乳腺炎性肌纖維母細胞瘤比較少見，形態多樣，併缺乏特異性免疫標記，病理診斷有時較睏難，應與一些梭形細胞腫瘤或病變鑒彆。
목적：탐토유선염성기섬유모세포류적림상병이학특정、진단화감별진단등。방법：대2례유선염성기섬유모세포류진행림상、병리형태이급면역조화표기，병복습상관문헌。결과：2례환자림상표현위유방종괴반유창통。대체상，종류절면회백、실성，가유점액감。경하，종괴변계청초혹자흠청，점액혹효원배경하류세포이사형세포위주，류세포무명현이형성，핵분렬상소견；간질혈관봉부，견림파세포、장세포등침윤。면역조화사형세포vimentin （＋），SMA、Desmin화 ALK불동정도（＋），이CK、S-100、Myogenin、bcl-2화CD34균（－）。결론：유선염성기섬유모세포류비교소견，형태다양，병결핍특이성면역표기，병리진단유시교곤난，응여일사사형세포종류혹병변감별。
Objective:To investigate the clinicopatholoical features and differential diagnosis of inflammatory myofibroblastic tumor ( IMT) in the breast. Methods: Two cases of IMT in the breast were retrospectively examined with regard to the clinical manifestations,histological findings and immunohisto-chemical markers,and related literatures were reviewed.Results: Two female patients generally complained of breast masses with occasional distending pain.Grossly,the specimen presented with solid mass,gray-white on cut sections and myxoid aspect.Microscopy revealed well or relatively poorly-defined tumor border,and that tumor was primarily composed of spindle cells against a myxoid and collagenous background with abundant stromal blood vessels and infiltration of lymphocytes and plasma cells.Cellular atypia and mitosis were rare.The tumor cells were immunoreactive to vimentin,SMA,Desmin,ALK, but negative for CK,S-100,bcl-2,Myogenin and CD34.Conclusion: IMT of the breast is extremely rare,and presents with multiple morphology,which makes difficult pathological diagnosis due to insufficient immunohistochemical markers available .Thus,differential diagnosis of this entity shall be distin-guished from other spindle cell carcinoma in the breast or similar lessions .lesion ical features,and has no specific immuno label.So,it is very difficult to make a diagnosis,which need to differentiate with some spindle cell carcinoma or lesions.
