皖南医学院学报
皖南醫學院學報
환남의학원학보
ACTA ACADEMIAE MEDICINAE WANNAN
2015年
2期
161-164,165
,共5页
肠杆菌科%抗菌药物%耐药变迁
腸桿菌科%抗菌藥物%耐藥變遷
장간균과%항균약물%내약변천
Enterobacteriaceae%antibiotic%drug resistance change
目的：了解常见临床分离肠杆菌科细菌对常用抗菌药物的耐药性及其变迁情况。为临床抗感染治疗选择用药提供参考依据。方法：收集2006～2013年我院细菌室从各类标本中分离出的菌株，对常见肠杆菌科细菌药物敏感性进行回顾性分析，用SPSS 13．0软件进行数据分析。结果：8年间共收集肠杆菌科细菌5797株。其中大肠埃希菌2470株，位居第一；其次为肺炎克雷伯菌，共2294株；再次为奇异变形杆菌，共316株。敏感性最高的抗菌药物为碳青霉烯类，其次为头胞哌酮舒巴坦。8年间大肠埃希菌、肺炎克雷伯菌ESBLs检出率分别为56．75％和32．18％。大肠埃希菌对头胞哌酮舒巴坦耐药率呈下降趋势，对头孢西丁耐药率呈上升趋势；肺炎克雷伯菌耐药性变化不大，对多数抗菌药物的耐药率低于大肠埃希菌。结论：碳青霉烯类对于常见肠杆菌科细菌有极高的抗菌活性；产ESBLs大肠埃希菌菌株呈增多趋势，多重耐药菌株增多，特别是近年来耐碳青霉烯类菌株增多，需引起重视并监测其变化趋势。
目的：瞭解常見臨床分離腸桿菌科細菌對常用抗菌藥物的耐藥性及其變遷情況。為臨床抗感染治療選擇用藥提供參攷依據。方法：收集2006～2013年我院細菌室從各類標本中分離齣的菌株，對常見腸桿菌科細菌藥物敏感性進行迴顧性分析，用SPSS 13．0軟件進行數據分析。結果：8年間共收集腸桿菌科細菌5797株。其中大腸埃希菌2470株，位居第一；其次為肺炎剋雷伯菌，共2294株；再次為奇異變形桿菌，共316株。敏感性最高的抗菌藥物為碳青黴烯類，其次為頭胞哌酮舒巴坦。8年間大腸埃希菌、肺炎剋雷伯菌ESBLs檢齣率分彆為56．75％和32．18％。大腸埃希菌對頭胞哌酮舒巴坦耐藥率呈下降趨勢，對頭孢西丁耐藥率呈上升趨勢；肺炎剋雷伯菌耐藥性變化不大，對多數抗菌藥物的耐藥率低于大腸埃希菌。結論：碳青黴烯類對于常見腸桿菌科細菌有極高的抗菌活性；產ESBLs大腸埃希菌菌株呈增多趨勢，多重耐藥菌株增多，特彆是近年來耐碳青黴烯類菌株增多，需引起重視併鑑測其變化趨勢。
목적：료해상견림상분리장간균과세균대상용항균약물적내약성급기변천정황。위림상항감염치료선택용약제공삼고의거。방법：수집2006～2013년아원세균실종각류표본중분리출적균주，대상견장간균과세균약물민감성진행회고성분석，용SPSS 13．0연건진행수거분석。결과：8년간공수집장간균과세균5797주。기중대장애희균2470주，위거제일；기차위폐염극뢰백균，공2294주；재차위기이변형간균，공316주。민감성최고적항균약물위탄청매희류，기차위두포고동서파탄。8년간대장애희균、폐염극뢰백균ESBLs검출솔분별위56．75％화32．18％。대장애희균대두포고동서파탄내약솔정하강추세，대두포서정내약솔정상승추세；폐염극뢰백균내약성변화불대，대다수항균약물적내약솔저우대장애희균。결론：탄청매희류대우상견장간균과세균유겁고적항균활성；산ESBLs대장애희균균주정증다추세，다중내약균주증다，특별시근년래내탄청매희류균주증다，수인기중시병감측기변화추세。
Objective:To investigate the commonly isolated strains of drug resistant Enterobacteriaceae in nosocomial settings and their distribution in order to supply evidence with rationale drug use in clinic.Methods:The total strains were isolated from specimens maintained in the bacterium laboratory of a hospital between 2006 and 2013.Sensitivity of the common gut Enterobacteriaceae to the currently available antibiotics was retrospectively examined through data analysis with SPSS13.0 software.Results:A total of 5 797 strains of Enterobacteriaceae were harvested in eight years,in which Escherichia coli stood top(2 470 strains) on the list,followed by Klebsiella pneumoniae(2 294 strains) and Proteus mirabilis(316 strains).The highest sensitivity of the above bacteria to antibiotics included carbapenem and Cefoperazone Shubatan .The detection rate of Escherichia coli and extended-spectrumβ-lactama-ses (ESBLs)production of by Klebsiella pneumoniae was 56.75% and 32.18%,respectively in 8-year-period.Resistance of Escherichia coli to Cefopera-zone Shubatan appeared to decline,yet tended to climb to Cefoxitin.Klebsiella pneumoniae resistance to available drugs remained little change ,and had lower resistance rate for most antibiotics than Escherichia coli .Conclusion:Carbapenems has higher antibacterial activity for common Enterobacteriaceae , and ESBLs-producing Escherichia coli strains as well as multi-drug resistant strains tend to climb ,especially rise of carbapenem-resistant strains in recent years,suggest that these strains require more intensive surveillance over their changes .
