CAJ | 학술논문

目的：探讨西咪替丁治疗轮状病毒肠炎患儿的疗效及其对血清白细胞介素-2(IL-2)、肿瘤坏死因子-α(TNF-α)的影响。方法80例轮状病毒肠炎患儿随机分为两组，每组40例，对照组给予抗病毒等常规治疗，观察组在对照组治疗的基础上加用西咪替丁治疗，比较两组患儿的临床疗效及治疗前后患者血清IL-2、TNF-α水平的变化。结果观察组治疗后总有效率为95%，明显高于对照组的80%，差异有统计学意义(P<0.05)；治疗后两组患儿血清IL-2均明显上升，TNF-α明显下降，且观察组IL-2高于对照组、TNF-α低于对照组，差异均有统计学意义(P<0.05)。结论西咪替丁可快速缓解轮状病毒肠炎患儿临床症状，并可调节患儿机体炎症免疫反应。
목적：탐토서미체정치료륜상병독장염환인적료효급기대혈청백세포개소-2(IL-2)、종류배사인자-α(TNF-α)적영향。방법80례륜상병독장염환인수궤분위량조，매조40례，대조조급여항병독등상규치료，관찰조재대조조치료적기출상가용서미체정치료，비교량조환인적림상료효급치료전후환자혈청IL-2、TNF-α수평적변화。결과관찰조치료후총유효솔위95%，명현고우대조조적80%，차이유통계학의의(P<0.05)；치료후량조환인혈청IL-2균명현상승，TNF-α명현하강，차관찰조IL-2고우대조조、TNF-α저우대조조，차이균유통계학의의(P<0.05)。결론서미체정가쾌속완해륜상병독장염환인림상증상，병가조절환인궤체염증면역반응。
Objective To investigate the efficacy of cimetidine in the treatment of children with rotavirus en-teritis and its effect on serum IL-2, TNF-α. Methods Eighty children with rotavirus enteritis were randomly divided into two groups, with 40 cases in each group. The control group received conventional antiviral treatment, and the ob-servation group was treated with cimetidine based on the treatment of the control group. Clinical efficacy and serum IL-2, TNF-αchanges were compared between the two groups after treatment. Results After treatment, the total ef-fective rate in the observation group (95%) was significantly higher than that in the control group (80%), and the dif-ference was statistically significant (P<0.05). Serum IL-2 was significantly increased and TNF-αwas significantly de-creased after treatment in the two groups. The IL-2 level in observation group was significantly higher than that in the control group, and TNF-αwas significantly lower (P<0.05). Conclusion Cimetidine can quickly relieve symptoms in children with rotavirus enteritis, and it can adjust the body's inflammatory immune response in children.