天津医药
天津醫藥
천진의약
TIANJIN MEDICAL JOURNAL
2015年
4期
439-442
,共4页
动脉粥样硬化%内皮,血管%脂蛋白类, HDL%功能性HDL%失功能性HDL
動脈粥樣硬化%內皮,血管%脂蛋白類, HDL%功能性HDL%失功能性HDL
동맥죽양경화%내피,혈관%지단백류, HDL%공능성HDL%실공능성HDL
atherosclerosis%endothelium,vascular%lipoproteins,HDL%functional HDL%dysfunctional HDL
在动脉粥样硬化病变的初始阶段，许多致动脉粥样硬化因素可损伤血管内皮，诱发内皮功能紊乱，内皮功能紊乱是动脉粥样硬化发病的重要机制。高密度脂蛋白（HDL）是由多种蛋白和脂质组成的功能复杂的脂蛋白。流行病学研究显示HDL与动脉粥样硬化呈负相关。HDL除参与胆固醇逆向转运、减少外周胆固醇堆积、防止泡沫细胞形成功能外，还可通过调节血管舒张功能、发挥抗氧化抗炎作用保护内皮功能，对抗动脉粥样硬化形成。但在冠心病患者体内存在失功能性HDL，其可能诱发内皮功能紊乱。本文就功能性HDL和失功能性HDL与内皮功能的关系进行综述。
在動脈粥樣硬化病變的初始階段，許多緻動脈粥樣硬化因素可損傷血管內皮，誘髮內皮功能紊亂，內皮功能紊亂是動脈粥樣硬化髮病的重要機製。高密度脂蛋白（HDL）是由多種蛋白和脂質組成的功能複雜的脂蛋白。流行病學研究顯示HDL與動脈粥樣硬化呈負相關。HDL除參與膽固醇逆嚮轉運、減少外週膽固醇堆積、防止泡沫細胞形成功能外，還可通過調節血管舒張功能、髮揮抗氧化抗炎作用保護內皮功能，對抗動脈粥樣硬化形成。但在冠心病患者體內存在失功能性HDL，其可能誘髮內皮功能紊亂。本文就功能性HDL和失功能性HDL與內皮功能的關繫進行綜述。
재동맥죽양경화병변적초시계단，허다치동맥죽양경화인소가손상혈관내피，유발내피공능문란，내피공능문란시동맥죽양경화발병적중요궤제。고밀도지단백（HDL）시유다충단백화지질조성적공능복잡적지단백。류행병학연구현시HDL여동맥죽양경화정부상관。HDL제삼여담고순역향전운、감소외주담고순퇴적、방지포말세포형성공능외，환가통과조절혈관서장공능、발휘항양화항염작용보호내피공능，대항동맥죽양경화형성。단재관심병환자체내존재실공능성HDL，기가능유발내피공능문란。본문취공능성HDL화실공능성HDL여내피공능적관계진행종술。
Chronic exposure to risk factors at the beginning stage of atherosclerosis development can damage endotheli?um and ultimately initiat endothelial dysfunction. Endothelial dysfunction is one of the major mechanisms in atherosclerosis development. High-density lipoprotein (HDL) is a lipoprotein with complicated function and is composed of a variety of pro?teins and lipids. Epidemiological studies showed an inverse correlation between HDL and atherosclerosis. The protective role of HDL on endothelium might related to its function in reversing cholesterol transport, reducing peripheral cholesterol accu?mulation, preventing foam cells formation, dilating vessels, antioxidant and anti-inflammation, all of which antagonize devel?opment of atherosclerosis. But HDL obtained from patients with cardiovascular disease which has known dysfunctional HDL may induce endothelial dysfunction. This review addresses the relationships between functional HDL or dysfunctional HDL with the endothelial function.
