CAJ | 학술논문

目的：探讨小剂量索利那新治疗小儿原发性夜间遗尿症的临床价值。方法78例原发性夜间遗尿症患儿随机分为治疗组和对照组（各39例）。2组患儿均接受行为干预治疗，治疗组同时给予索利那新（5 mg/片，1/3片，每天1次）。2组均治疗3个月并随访3个月，记录2组患儿的疗效及复发率。结果疗程结束时和随访3个月治疗组有效率均高于对照组（89.7%vs 69.2%，82.1%vs 46.2%，均P<0.05）。随访观察3个月，治疗组复发率低于对照组（8.6%vs 33.3%，P<0.05）。结论小剂量索利那新治疗小儿遗尿症安全、有效，配合行为干预治疗可提高疗效，减少复发。
목적：탐토소제량색리나신치료소인원발성야간유뇨증적림상개치。방법78례원발성야간유뇨증환인수궤분위치료조화대조조（각39례）。2조환인균접수행위간예치료，치료조동시급여색리나신（5 mg/편，1/3편，매천1차）。2조균치료3개월병수방3개월，기록2조환인적료효급복발솔。결과료정결속시화수방3개월치료조유효솔균고우대조조（89.7%vs 69.2%，82.1%vs 46.2%，균P<0.05）。수방관찰3개월，치료조복발솔저우대조조（8.6%vs 33.3%，P<0.05）。결론소제량색리나신치료소인유뇨증안전、유효，배합행위간예치료가제고료효，감소복발。
Objective To evaluate the clinical value of small doses of solifenacin to treat children of primary nocturnal enuresis. Methods Children (n=78) of primary nocturnal enuresis were randomly divided into treatment group(39 cases) and control group(39 cases). All children received behavioral intervention therapy, while children in the treatment group were given Solifenacin(5 mg/tablet, 1/3 tablet, 1 times a day for 3 months) orally besides behavioral therapy. Children were followed up for 3 months after the end of the treatment, and the curative effect and recurrence rate were compared between two groups. Results Compared with that of children in control group, cure rate of children in treatment group is higher at the end of treatment (89.7%vs 69.2%, P<0.05) as well as by 3 month of follow-up time (82.1%vs 46.2%, P<0.05). The re?currence rate of children in treatment group, by three months follow-up time, was lower than that of children in control group (8.6%vs 33.3%,P<0.05). Conclusion Small dose of Solifenacin in addition to behavioral intervention is safe and effec?tive in treatment of children with enuresis, which enhance cure rate and reduce recurrence.