CAJ | 학술논문

逐渐增多的研究表明,人们生活中经常接触到的一些化学物质是导致乳腺癌发生的危险因素；同时一些研究证实,Hedgehog (Hh)信号通路在乳腺癌患者组织中存在异常激活,参与乳腺癌的发生、调节乳腺癌干细胞生物学特性、促进肿瘤组织血管新生和乳腺癌细胞侵袭转移等生物学过程。本文通过对化学物质与 Hh 信号通路在乳腺癌发生、发展研究的最新进展进行综述,为进一步阐述乳腺癌发病机制和乳腺癌的预防及控制提供科学线索。
축점증다적연구표명,인문생활중경상접촉도적일사화학물질시도치유선암발생적위험인소；동시일사연구증실,Hedgehog (Hh)신호통로재유선암환자조직중존재이상격활,삼여유선암적발생、조절유선암간세포생물학특성、촉진종류조직혈관신생화유선암세포침습전이등생물학과정。본문통과대화학물질여 Hh 신호통로재유선암발생、발전연구적최신진전진행종술,위진일보천술유선암발병궤제화유선암적예방급공제제공과학선색。
The controversial results of several studies suggest that certain everyday-use chemicals may be linked to breast cancer. ln recent years, extensive researches have been carried out to under-stand breast carcinogenesis and the hedgehog(Hh) signaling pathway has emerged as a critical determi-nant of human breast cancer. Aberrant Hh signaling in adults results in carcinogenesis, angiogenesis, and metastasis. This review is focused on the Hh signaling pathway and chemicals in the regulation of breast cancer development and provide an updated survey of pre-clinical and clinical trials of novel strategies to target them.