CAJ | 학술논문

目的：研究该院住院患者抗菌药物联合使用情况，发现和纠正不合理联合用药现象，以促进临床合理用药。方法随机抽取该院2013年10月住院患者病历，采用回顾性调查方法，从中筛取使用抗菌药物的病历共288份，其中联合用药病例共225份，统计出每份病历联合用药方式、品种及主要病症情况。结果抗菌药物联合用药病历占使用抗菌药物病历的78.13%。其中以二联用药为主，合理联合用药占联合用药病历的88.00%。不合理联合用药中无指征用药占多数，比例占不合理联合用药的44.44%，药效学配伍禁忌占37.04%，药动学配伍禁忌占18.52%。结论掌握抗菌药物联合用药适应证及药物之间相互作用等特征，才能使联合用药疗效增强。
목적：연구해원주원환자항균약물연합사용정황，발현화규정불합리연합용약현상，이촉진림상합리용약。방법수궤추취해원2013년10월주원환자병력，채용회고성조사방법，종중사취사용항균약물적병력공288빈，기중연합용약병례공225빈，통계출매빈병력연합용약방식、품충급주요병증정황。결과항균약물연합용약병력점사용항균약물병력적78.13%。기중이이련용약위주，합리연합용약점연합용약병력적88.00%。불합리연합용약중무지정용약점다수，비례점불합리연합용약적44.44%，약효학배오금기점37.04%，약동학배오금기점18.52%。결론장악항균약물연합용약괄응증급약물지간상호작용등특정，재능사연합용약료효증강。
Objective?This?paper?aims?to?delve?into?the?inpatients’?combined?application?of?antibiotics?in?our?hospital,?and?to?discover?and?correct?improper?combined?medication?and?promote?proper?clinical?medication.?Methods?Inpatients'?medical?records?from?our?hospital?in?October,?2013?were?randomly?selected?and?a?retrospective?investigation?approach?was?adopted?to?select?288?case?with?antibiotics?medication,?in?which?225?are?of?combined?medication.?The?way?and?category?of?combined?medication,?main?symptoms?were?gain?of?each?department.Results?Combined?medication?in?these?three?departments?were?found?78.13%?of?the?total?antibiotics?application.?The?most?frequently?used?is?two?kinds?combined?medication,?Among?them,?88.00?%?are?of?proper?application?where?44.44%?are?no-indication?medication,?37.04%?are?pharmacodynamic?incompatibility?and?18.52%?are?pharmacokinetic?incompatibility. Conclusion?Only?we?master?the?adaptive?disease?of?antibiotics?application?and?interaction?of?different?drugs?can?we?make?combined?medication?proper?and?reinforce?effects.