CAJ | 학술논문

类风湿关节炎（ rheumatoid arthritis，RA）是一种累及多关节的慢性系统性炎性自身免疫性疾病。近年来，研究一直专注于预测疾病发病、疾病进展、关节损伤和治疗反应的生物标记物。白色脂肪组织作为一种多效性器官，不仅具有内分泌功能，而且参与多种病理生理过程，包括免疫和炎性反应。白色脂肪组织分泌的脂肪细胞因子，参与RA的发病。该文对可能作为疾病活动和治疗反应的潜在生物标记物的脂肪细胞因子的研究进展进行综述。
류풍습관절염（ rheumatoid arthritis，RA）시일충루급다관절적만성계통성염성자신면역성질병。근년래，연구일직전주우예측질병발병、질병진전、관절손상화치료반응적생물표기물。백색지방조직작위일충다효성기관，불부구유내분비공능，이차삼여다충병리생리과정，포괄면역화염성반응。백색지방조직분비적지방세포인자，삼여RA적발병。해문대가능작위질병활동화치료반응적잠재생물표기물적지방세포인자적연구진전진행종술。
Rheumatoid arthritis ( RA) is a chronic multisystem systemic inflammatory utoimmune disease characterized by polyarticular injury.Recently,research has been focusing on the possible identification of predictor markers of disease onset and/or progression,of joint damage,and of therapeutic response.Recent findings have uncovered the role of white adipose tissue as a pleiotropic organ not on-ly specialized in endocrine functions but also able to control multiple physiopathological processes,including autoimmune and inflamma-tion.Adipokines are secreted by white adipose tissue which involved in the pathogenesis of RA.This review will focus on the recent advances on the adipokines as potential biomarkers of disease activity and therapeutic response.