CAJ | 학술논문

目的：探讨丁香酚通过嗅觉通路对自闭症鼠社交行为的影响。方法大鼠孕后12．5 d腹腔注射丙戊酸钠（ Valproate VPA）600 mg· kg－1制备自闭症动物模型。观察丁香酚干预后自闭症鼠在社交行为实验中社交行为次数和持续时间情况。结果丁香酚吸嗅后，自闭症鼠社交行为次数较前增加（P＜0．05），社交持续时间较前延长（P＜0．05）。结论丁香酚吸入对自闭症大鼠社交行为有一定的改善作用。
목적：탐토정향분통과후각통로대자폐증서사교행위적영향。방법대서잉후12．5 d복강주사병무산납（ Valproate VPA）600 mg· kg－1제비자폐증동물모형。관찰정향분간예후자폐증서재사교행위실험중사교행위차수화지속시간정황。결과정향분흡후후，자폐증서사교행위차수교전증가（P＜0．05），사교지속시간교전연장（P＜0．05）。결론정향분흡입대자폐증대서사교행위유일정적개선작용。
Objective To study the effect of eugenol by olfactory pathway on social behavior of autism rats.Methods The model of autism was established by the single intraperitoneal injection of 600 mg· kg-1 sodium valproate on the 12.5 day of pregnant rats.We performed social interaction test to investigate social deficits of the rats.Results The eugenol group increased the number of social in-teraction(P<0.05),as well as extended the duration of social behavior(P<0.05) after treatment.Conclusion Eugenol by olfactory pathway can improve the social behavior of autism rats.