广西医学
廣西醫學
엄서의학
GUANGXI MEDICAL JOURNAL
2015年
2期
195-197
,共3页
黄海燕%黄国盛%毕雷%黄培禄
黃海燕%黃國盛%畢雷%黃培祿
황해연%황국성%필뢰%황배록
呼吸暂停%早产儿%枸橼酸咖啡因%氨茶碱
呼吸暫停%早產兒%枸櫞痠咖啡因%氨茶堿
호흡잠정%조산인%구연산가배인%안다감
Apnea%Premature infants%Caffeine citrate%Aminophylline
目的：探讨枸橼酸咖啡因治疗早产儿原发性呼吸暂停的有效性及安全性。方法将发生原发性呼吸暂停需使用呼吸兴奋药物治疗的早产儿（胎龄28～34周）73例，按随机数字表法分为观察组35例和对照组38例。观察组应用枸橼酸咖啡因注射液，对照组应用氨茶碱静脉输注。观察两组疗效及不良反应。结果用药后第3天、第7天观察组有效率分别为91．43％（32／35）和94．28％（33／35），均高于对照组的73．68％（28／38）和76．32％（29／38）（P均＜0．05）。观察组心率增快、血压升高、尿多、体重不增、胃潴留或喂养不耐受等各项不良反应发生率与对照组比较，差异无统计学意义（P＞0．05），但总不良反应发生率[14．29％（5／35）]明显低于对照组[52．63％（20／38）]（P＜0．05）。两组病例均无神经系统不良反应。结论枸橼酸咖啡因治疗早产儿原发性呼吸暂停与氨茶碱比较效果更好，不良反应较少，安全有效。
目的：探討枸櫞痠咖啡因治療早產兒原髮性呼吸暫停的有效性及安全性。方法將髮生原髮性呼吸暫停需使用呼吸興奮藥物治療的早產兒（胎齡28～34週）73例，按隨機數字錶法分為觀察組35例和對照組38例。觀察組應用枸櫞痠咖啡因註射液，對照組應用氨茶堿靜脈輸註。觀察兩組療效及不良反應。結果用藥後第3天、第7天觀察組有效率分彆為91．43％（32／35）和94．28％（33／35），均高于對照組的73．68％（28／38）和76．32％（29／38）（P均＜0．05）。觀察組心率增快、血壓升高、尿多、體重不增、胃潴留或餵養不耐受等各項不良反應髮生率與對照組比較，差異無統計學意義（P＞0．05），但總不良反應髮生率[14．29％（5／35）]明顯低于對照組[52．63％（20／38）]（P＜0．05）。兩組病例均無神經繫統不良反應。結論枸櫞痠咖啡因治療早產兒原髮性呼吸暫停與氨茶堿比較效果更好，不良反應較少，安全有效。
목적：탐토구연산가배인치료조산인원발성호흡잠정적유효성급안전성。방법장발생원발성호흡잠정수사용호흡흥강약물치료적조산인（태령28～34주）73례，안수궤수자표법분위관찰조35례화대조조38례。관찰조응용구연산가배인주사액，대조조응용안다감정맥수주。관찰량조료효급불량반응。결과용약후제3천、제7천관찰조유효솔분별위91．43％（32／35）화94．28％（33／35），균고우대조조적73．68％（28／38）화76．32％（29／38）（P균＜0．05）。관찰조심솔증쾌、혈압승고、뇨다、체중불증、위저류혹위양불내수등각항불량반응발생솔여대조조비교，차이무통계학의의（P＞0．05），단총불량반응발생솔[14．29％（5／35）]명현저우대조조[52．63％（20／38）]（P＜0．05）。량조병례균무신경계통불량반응。결론구연산가배인치료조산인원발성호흡잠정여안다감비교효과경호，불량반응교소，안전유효。
Objective To investigate the efficacy and safety of caffeine citrate in the treatment of primary apnea in preterm infants.Methods Seventy-three preterm infants with primary apnea(gestational ages of 28 to 34 weeks)receiving respiratory stimulant drug treatment were randomly divided into two groups ,35 cases in the observation group and 38 cases in the control group .The observation group was given caffeine citrate injection,while the control group was given intravenous drip of aminophylline .The efficacy and adverse reaction were compared between two groups.Results The effective rates of observation group on the third and seventh day after administration were 91.43%(32/35) and 94.28%(33/35),respectively,which were higher than those (73.68[28/38],76.32%[29/38]) of control group(all P<0.05).No significant differences were found in the incidences of adverse reactions such as increased heart rate ,raised blood pressure, increased urine,no weight gain,gastric retention and feeding intolerance between two groups (P>0.05).But the overall incidence of adverse reactions of observation group was significantly lower than that of control group (14.29%[5/35] vs.52.63%[20/38],P<0.05).No adverse reactions of nervous system occurred in two groups .Conclusion Compared with aminophylline ,caffeine citrate owns better effects and less adverse reactions in the treatment of premature infants with primary apnea .It is safe and effective .
