CAJ | 학술논문

详尽形态分析信息，应包括物质内部状态、空间状态、时间状态，涵盖所含元素种类与数量，元素状态（价态差异、原子结构状态差异即同位素现象），元素间相互作用（原子间作用力，各原子相对空间结构），物质在各层，层中各微区中分布状况，研究物质与其他物质相互间作用力和相对空间坐标，研究物质内部及空间状态随时间的变异。可据学科特性、研究目的、研究对象初步界定物质形态，体现药效、环境效应、生物可给性、生物富集能力、生物地球化学循环行为差异。胃肠仿生消化和肠道吸收模型构建是食品药品生物可给性评价基础。本文将据探讨中药微量元素形态与生物可给性研究新策略。
상진형태분석신식，응포괄물질내부상태、공간상태、시간상태，함개소함원소충류여수량，원소상태（개태차이、원자결구상태차이즉동위소현상），원소간상호작용（원자간작용력，각원자상대공간결구），물질재각층，층중각미구중분포상황，연구물질여기타물질상호간작용력화상대공간좌표，연구물질내부급공간상태수시간적변이。가거학과특성、연구목적、연구대상초보계정물질형태，체현약효、배경효응、생물가급성、생물부집능력、생물지구화학순배행위차이。위장방생소화화장도흡수모형구건시식품약품생물가급성평개기출。본문장거탐토중약미량원소형태여생물가급성연구신책략。
The all-around speciation, we thought, should give such information as the inside, space and time state of studied substance. The inside state includes the kind, amount, valence state, atomic structure of elements, the interaction and space structure between elements. The space state means the distributing of studied object on different layer, different tiny section in same layer, interaction and space between object and other substance. The time state indicates the variation of inside and space state during times. So all-around speciation could be divided into the states of valence, chemical combination, binding, space structure, and all kinds of physical dispersive state, according to the demands by different subject, research aim and object. These classificatory of speciation, we thought, could be enough to identify the different environmental effect, bioavailability, bioaccumulation, transformation and transport among species of studied substance. Biomimetic gastrointestinal digestion and absorption system could be used for speciation analysis and bioavailability assessment of trace elements in traditional Chinese medicine.