牙体牙髓牙周病学杂志
牙體牙髓牙週病學雜誌
아체아수아주병학잡지
CHINESE JOURNAL OF CONSERVATIVE DENTISTRY
2015年
3期
175-178
,共4页
陈婵婵(综述)%凌均蓕(审校)
陳嬋嬋(綜述)%凌均蓕(審校)
진선선(종술)%릉균계(심교)
Wnt 信号通路%牙齿发育%牙囊%成骨向分化
Wnt 信號通路%牙齒髮育%牙囊%成骨嚮分化
Wnt 신호통로%아치발육%아낭%성골향분화
Wnt signalling pathways%tooth development%dental follicles%osteogenic differentiation
Wnt 信号通路包括经典 Wnt/β-catenin 信号通路和非经典通路,对个体组织发育和干细胞的自我更新具有重要调控作用,在包括颅面部器官在内的几乎所有器官发生过程中都必需 Wnt 信号通路的调控。研究发现,Wnt/β-catenin 信号通路不仅在牙齿发育过程中参与了上皮和间充质的相互作用,在牙囊细胞的分化过程亦有 Wnt 信号通路的参与。本文就 Wnt 信号通路在牙齿发育和牙囊成骨/成牙骨质向分化中的调控作用研究进展作一综述。
Wnt 信號通路包括經典 Wnt/β-catenin 信號通路和非經典通路,對箇體組織髮育和榦細胞的自我更新具有重要調控作用,在包括顱麵部器官在內的幾乎所有器官髮生過程中都必需 Wnt 信號通路的調控。研究髮現,Wnt/β-catenin 信號通路不僅在牙齒髮育過程中參與瞭上皮和間充質的相互作用,在牙囊細胞的分化過程亦有 Wnt 信號通路的參與。本文就 Wnt 信號通路在牙齒髮育和牙囊成骨/成牙骨質嚮分化中的調控作用研究進展作一綜述。
Wnt 신호통로포괄경전 Wnt/β-catenin 신호통로화비경전통로,대개체조직발육화간세포적자아경신구유중요조공작용,재포괄로면부기관재내적궤호소유기관발생과정중도필수 Wnt 신호통로적조공。연구발현,Wnt/β-catenin 신호통로불부재아치발육과정중삼여료상피화간충질적상호작용,재아낭세포적분화과정역유 Wnt 신호통로적삼여。본문취 Wnt 신호통로재아치발육화아낭성골/성아골질향분화중적조공작용연구진전작일종술。
Abstract] Wnt signalling pathways include the canonical Wnt pathway and non -canonical pathways.Grow-ing evidence indicates that Wnt signaling pathways orchestrate tissue development and stem cell self-renewal.Wnt/β-catenin signaling is known to be crucial for tooth development and bone formation.Furthermore,several members of the Wnt family were observed in the presumptive dental epithelium or mesenchyme.The differentiation of dental follicle cells needs the regulation of Wnt signaling.This review emphasizes the role of Wnt signalling pathways in tooth devel-opment and the osteogenic differentiation of dental follicle.