临床荟萃
臨床薈萃
림상회췌
CLINICAL FOCUS
2015年
4期
408-411,415
,共5页
食管肿瘤%癌,鳞状细胞%血小板增多
食管腫瘤%癌,鱗狀細胞%血小闆增多
식관종류%암,린상세포%혈소판증다
esophageal neoplasms%squamous cell carcinoma%thrombocytosis
目的：探讨术前血小板(PLT)增多与食管鳞癌患者临床病理特征及预后的相关性。方法回顾性分析行根治性手术切除的169例食管鳞癌患者的临床病理资料。术前 PLT 正常140例,PLT 增多29例,分析 PLT 增多与临床病理因素的关系,采用 Cox 比例风险模型进行多因素生存分析。结果本研究食管鳞癌患者 PLT 增多发生率为17.2%(29/169),PLT 增多与肿瘤直径、淋巴结转移、TNM 分期有关(χ2=10.301,4.130,6.152,P <0.05)。PLT增多患者的5年生存率为6.9%,PLT 正 常 患 者 的5年 生 存 率 为 33.2%,差异具有统计学意义(χ2= 12.339,P <0.01)；吸烟史、肿瘤大小、肿瘤浸润深度、有无淋巴结转移及 PLT 增多是影响患者5年生存率的因素(χ2=4.195,4.164,7.816,18.328,12.339,均 P <0.05),进一步分析显示,在无淋巴结转移及有淋巴结转移的患者中,PLT 正常与 PLT 增多患者的5年生存率差异均有统计学意义(χ2=4.018、4.810,P <0.05)。淋巴结转移(OR =2.057,P =0.001)及 PLT 增多(OR =1.911,P =0.003)是影响患者预后的独立危险因素。结论术前 PLT 增多提示患者预后不良,是影响食管鳞癌患者预后的独立危险因素。
目的：探討術前血小闆(PLT)增多與食管鱗癌患者臨床病理特徵及預後的相關性。方法迴顧性分析行根治性手術切除的169例食管鱗癌患者的臨床病理資料。術前 PLT 正常140例,PLT 增多29例,分析 PLT 增多與臨床病理因素的關繫,採用 Cox 比例風險模型進行多因素生存分析。結果本研究食管鱗癌患者 PLT 增多髮生率為17.2%(29/169),PLT 增多與腫瘤直徑、淋巴結轉移、TNM 分期有關(χ2=10.301,4.130,6.152,P <0.05)。PLT增多患者的5年生存率為6.9%,PLT 正 常 患 者 的5年 生 存 率 為 33.2%,差異具有統計學意義(χ2= 12.339,P <0.01)；吸煙史、腫瘤大小、腫瘤浸潤深度、有無淋巴結轉移及 PLT 增多是影響患者5年生存率的因素(χ2=4.195,4.164,7.816,18.328,12.339,均 P <0.05),進一步分析顯示,在無淋巴結轉移及有淋巴結轉移的患者中,PLT 正常與 PLT 增多患者的5年生存率差異均有統計學意義(χ2=4.018、4.810,P <0.05)。淋巴結轉移(OR =2.057,P =0.001)及 PLT 增多(OR =1.911,P =0.003)是影響患者預後的獨立危險因素。結論術前 PLT 增多提示患者預後不良,是影響食管鱗癌患者預後的獨立危險因素。
목적：탐토술전혈소판(PLT)증다여식관린암환자림상병리특정급예후적상관성。방법회고성분석행근치성수술절제적169례식관린암환자적림상병리자료。술전 PLT 정상140례,PLT 증다29례,분석 PLT 증다여림상병리인소적관계,채용 Cox 비례풍험모형진행다인소생존분석。결과본연구식관린암환자 PLT 증다발생솔위17.2%(29/169),PLT 증다여종류직경、림파결전이、TNM 분기유관(χ2=10.301,4.130,6.152,P <0.05)。PLT증다환자적5년생존솔위6.9%,PLT 정 상 환 자 적5년 생 존 솔 위 33.2%,차이구유통계학의의(χ2= 12.339,P <0.01)；흡연사、종류대소、종류침윤심도、유무림파결전이급 PLT 증다시영향환자5년생존솔적인소(χ2=4.195,4.164,7.816,18.328,12.339,균 P <0.05),진일보분석현시,재무림파결전이급유림파결전이적환자중,PLT 정상여 PLT 증다환자적5년생존솔차이균유통계학의의(χ2=4.018、4.810,P <0.05)。림파결전이(OR =2.057,P =0.001)급 PLT 증다(OR =1.911,P =0.003)시영향환자예후적독립위험인소。결론술전 PLT 증다제시환자예후불량,시영향식관린암환자예후적독립위험인소。
Objective To explore the association of preoperative thrombocytosis with the clinicopathologic features and the prognosis of esophageal squamous cell carcinoma patients after surgical resection.Methods The clinical data of 1 69 patients with histologically proven esophageal squamous cell carcinoma, receiving curative resection,were retrospectively analyzed.Of all patients,140 cases were with normal level of platelet and 29 cases were with thrombocytosis.The relationship between thrombocytosis and the clinicopathological features were studied using Chi-square test and the postoperative prognostic factors were analyzed using univariate Kaplan-Meier analysis and multivariate Cox proportional hazards model.Results The thrombocytosis incidence was 1 7.2%(29/1 69),which was correlated with tumor size,lymph node metastasis and TNM staging,respectively (χ2 = 10.301,4.130 and 6.1 52, respectively;P < 0.05 ).The 5-year survival rate of the patients with or without thrombocytosis were 6.9% and 33.2%,showing a statistically significant difference (χ2 = 12.339,P <0.01 ).Univariate analysis showed smoking status,tumor size,the depth of invasion,lymph node metastasis and thrombocytosis were prominently associated with the survival rate of the patients, respectively (χ2 = 4.1 95,4.1 64,7.81 6,18.328 and 12.339,all P < 0.05 ). Multivariate analysis revealed that lymph node metastasis and thrombocytosis were two independent prognostic factors for the patients (OR =2.057 and 1.91 1,P =0.001 and P =0.003,respectively).Furthermore,the 5-year survival rate of the patients with or without thrombocytosis showed statistically significant difference in both patients with or without lymph node metastasis (χ2 =4.018 and 4.810,P <0.05).Conclusion Preoperative thrombocytosis indicates poor prognosis in patients with esophageal squamous cell carcinoma.It is an independent prognosis factor for the patients with esophageal squamous cell carcinoma after curative resection.
