CAJ | 학술논문

目的：探讨南京地区慢性丙型肝炎患者丙型肝炎病毒(hepatitis C virus,HCV)基因型分布特征和相关的影响因素,以对 HCV 感染的控制和个体化治疗提供依据。方法收集南京市第二医院慢性丙型肝炎患者1030例,采用基因芯片法检测 HCV 患者基因型,分析 HCV 基因型的组成及其与性别、年龄的关系。结果本研究中南京地区基因型有1a,1b,2a,3a,3b,6型和少量混合型,1b 型占73.0%(752/1030),其次为2a 型占9.4%(97/1030),未见4型和5型；在男女慢性 HCV 患者中,1b 型均为主要基因型,1b 型在男性组中比例明显高于女性组,差异有统计学意义(P <0.01)；1b 型与2a 型患者平均年龄大于3b 型患者,差异有统计学意义(P <0.01)。结论南京地区 HCV 基因型以1b 型为主,其次为2a 型,未见4 型、5型；3b 型患者的平均年龄均比1b 型和2a 型患者小。
목적：탐토남경지구만성병형간염환자병형간염병독(hepatitis C virus,HCV)기인형분포특정화상관적영향인소,이대 HCV 감염적공제화개체화치료제공의거。방법수집남경시제이의원만성병형간염환자1030례,채용기인심편법검측 HCV 환자기인형,분석 HCV 기인형적조성급기여성별、년령적관계。결과본연구중남경지구기인형유1a,1b,2a,3a,3b,6형화소량혼합형,1b 형점73.0%(752/1030),기차위2a 형점9.4%(97/1030),미견4형화5형；재남녀만성 HCV 환자중,1b 형균위주요기인형,1b 형재남성조중비례명현고우녀성조,차이유통계학의의(P <0.01)；1b 형여2a 형환자평균년령대우3b 형환자,차이유통계학의의(P <0.01)。결론남경지구 HCV 기인형이1b 형위주,기차위2a 형,미견4 형、5형；3b 형환자적평균년령균비1b 형화2a 형환자소。
ABSTRACT:Objective To provide evidence for controlling HCV infection and HCV-personalized medicine,the characterisitcs of hepatitis C virus (HCV)genotyping distribution in patients with chronic hepatitis C virus in Nanjing area and related factors were analyzed.Methods A total of 1 030 blood samples from chronic hepatitis C patients in the Second Hospital of Nanjing were collected.HCV genotyping was verified by gene chip.The relationships between HCV genotyping,gender and age were analyzed.Results Seven different HCV genotypes were found,including 1a, 1b,2a,3a,3b,6 and few mixed-genotypes,and genotypes 1b and 2a accounted for 73.0% (752/1 030)and 9.4%(97/1 030),respectively.There were no genotypes 4 and 5 found in the study.Genotype 1b was the most common genotyping in both male and female patients,while the percentage of genotype 1b was significantly higher in male than in female (P <0.01).The average age of patients with genotype 1b or 2a was significantly older than that of genotype 3b (P < 0.01 ).Conclusion HCV genotype 1b was the most common genotyping in Nanjing area,followed by genotype 2a.Genotypes including 1a,3a,3b and 6 were found except for genotypes 4 and 5.The average age of patients with genotype 3b is younger than that with genotype 1b or 2a.