CAJ | 학술논문

近年来，抑癌基因与肿瘤之间的关系成为一个新的研究关注焦点。腺瘤性结肠息肉病（APC）基因是一种多功能抑癌基因，不仅参与Wnt信号途径，调节β-连环蛋白（β-catenin）的降解，同时也调节细胞骨架运动，调控细胞的周期，影响细胞的迁移与分裂等，APC表达的（下调或缺失）异常与肿瘤的发生发展密切相关。本文就APC结构和功能及其失活与肿瘤的关系作一综述。
근년래，억암기인여종류지간적관계성위일개신적연구관주초점。선류성결장식육병（APC）기인시일충다공능억암기인，불부삼여Wnt신호도경，조절β-련배단백（β-catenin）적강해，동시야조절세포골가운동，조공세포적주기，영향세포적천이여분렬등，APC표체적（하조혹결실）이상여종류적발생발전밀절상관。본문취APC결구화공능급기실활여종류적관계작일종술。
In recent years and the relationship between the tumor suppressor gene become the hot topic of the research.Colon adenomatous polyposis(APC)gene is a kind of multi-functional tumor-suppressor genes,which not only participate in the Wnt signaling pathways,adjust the beta serial(beta-catenin)protein degradation,but also adjust the cytoskeleton,regulation of cel cycle,affecting cel migration and division of APC expression(cut or missing) anomaly is closely related to the occurrence of tumor development.In this paper,the structure and function of APC and its deactivation and the relationship between the tumor.