CAJ | 학술논문

目的：探讨降钙素原（Procalcitonin，PCT）在新生儿严重感染性疾病早期诊断的临床应用价值。方法：选取新生儿99例作为研究对象，分成非感染组（A组）、局部感染组（B组）及重症感染组（C组），每组各33例。比较三组中降钙素原（PCT）、白介素6（IL－6）、C反应蛋白（CRP）含量。结果：C组的血清PCT、IL－6、CRP浓度均明显升高，其中，PCT升高更显著（P＜0．01）；与A、B两组比较，C组的PCT阳性率差异具有统计学意义（P＜0．05），与CRP、IL－6的阳性率相比差异具有统计学意义（P＜0．05），与IL－6、CRP比较，PCT在重症感染的诊断中，特异性及敏感性更高。结论：PCT的诊断价值明显好于IL－6和CRP，可作为早期检测新生儿严重感染的标准，在诊断和预后中均有重要意义。
목적：탐토강개소원（Procalcitonin，PCT）재신생인엄중감염성질병조기진단적림상응용개치。방법：선취신생인99례작위연구대상，분성비감염조（A조）、국부감염조（B조）급중증감염조（C조），매조각33례。비교삼조중강개소원（PCT）、백개소6（IL－6）、C반응단백（CRP）함량。결과：C조적혈청PCT、IL－6、CRP농도균명현승고，기중，PCT승고경현저（P＜0．01）；여A、B량조비교，C조적PCT양성솔차이구유통계학의의（P＜0．05），여CRP、IL－6적양성솔상비차이구유통계학의의（P＜0．05），여IL－6、CRP비교，PCT재중증감염적진단중，특이성급민감성경고。결론：PCT적진단개치명현호우IL－6화CRP，가작위조기검측신생인엄중감염적표준，재진단화예후중균유중요의의。
Objective To investigate function and significance ofprocalationin (PCT)in early diagnosis.Methods 99 patients were divided into three groups:severe infection group ,focal infection group and noninfection group.Their serum PCT,CRP and IL-6 level were detected.Results PCT、CRP and IL-6 blood level increased significantly in severe infection disease,but PCT in-creased more significantly (P<0. 01).PCT positive rate in serious infection group had extreme significance compared with other two groups (P<0. 01),besides the difference between PCT and CRP,PCT and IL -6 were significantly in the three groups (P<0. 05).PCT has higher sensibility and the speciality in diagnosis of sevece infection disease compared with CRP and IL-6.Conclu-sion PCT increase in severe neonatal bacterial infectious disease,therefore,it can be used as early diagnosis mark in neonatal infec-tious disease.Its diagnosis value is better than CRP and IL-6,PCT has important signifi-cance in early diagnosis and evaluation of patients prognosis.