CAJ | 학술논문

目的：：探讨特异性尘螨过敏原免疫疗法辅助信必可都保(布地奈德福莫特罗粉吸入剂)雾化吸入治疗中重度支气管哮喘临床效果及安全性。方法：2012年5月—2013年1月选取本院中重度支气管哮喘患者130例，采用随机数字表法分为对照组和试验组，每组65例；其中对照组患者采用信必可都保雾化吸入治疗，试验组患者则在此基础上加用特异性尘螨过敏原免疫疗法；比较两组患者临床疗效，治疗前后肺部通气功能指标，哮喘症状评分、哮喘生活质量评分及治疗期间不良反应发生情况等。结果：试验组患者临床疗效显著优于对照组( P<0.05)；两组患者治疗后肺部通气功能指标水平、哮喘症状评分及哮喘生活质量评分较治疗前均显著改善，且试验组患者治疗后各项指标水平优于对照组( P<0.05)；两组患者治疗期间不良反应总发生率比较差异无统计学意义( P>0.05)。结论：特异性尘螨过敏原免疫疗法辅助信必可都保雾化吸入治疗中重度支气管哮喘可有效缓解症状体征，提高肺部通气功能和生活质量，且未增加不良反应发生风险。
목적：：탐토특이성진만과민원면역요법보조신필가도보(포지내덕복막특라분흡입제)무화흡입치료중중도지기관효천림상효과급안전성。방법：2012년5월—2013년1월선취본원중중도지기관효천환자130례，채용수궤수자표법분위대조조화시험조，매조65례；기중대조조환자채용신필가도보무화흡입치료，시험조환자칙재차기출상가용특이성진만과민원면역요법；비교량조환자림상료효，치료전후폐부통기공능지표，효천증상평분、효천생활질량평분급치료기간불량반응발생정황등。결과：시험조환자림상료효현저우우대조조( P<0.05)；량조환자치료후폐부통기공능지표수평、효천증상평분급효천생활질량평분교치료전균현저개선，차시험조환자치료후각항지표수평우우대조조( P<0.05)；량조환자치료기간불량반응총발생솔비교차이무통계학의의( P>0.05)。결론：특이성진만과민원면역요법보조신필가도보무화흡입치료중중도지기관효천가유효완해증상체정，제고폐부통기공능화생활질량，차미증가불량반응발생풍험。
Objective:To investigate clinical effects and safety of specific dust mite allergen immunotherapy combined with Symbicort Turbuhaler inhalation in treatment of bronchial asthma with medium type and severe type.Methods:130 patients with bronchial asthma with medium type and severe type were chosen and randomly divided into both group including control group ( 65 patients) with Symbicort Turbuhaler inhalation treatment and experiment group ( 65 patients) with specific dust mite allergen immunotherapy on the basis of control group;and the clinical efficacy, before and after treatment pulmonary ventilation function index, asthma symptom score, life quality score of asthma and adverse effects occurrence of both groups were compared.Results:The clinical efficacy of experiment group was significantly better than control group ( P<0. 05 ) . The after treatment pulmonary ventilation function index, asthma symptom score, life quality score of asthma of both groups was significantly better than before treatment ( P<0. 05 ) . The indexes above of experiment group was significantly better than control group( P<0.05) . There was no significant difference in adverse effects occurrence between 2 groups ( P>0.05).Conclusion:Specific dust mite allergen immunotherapy combined with Symbicort Turbuhaler inhalation in treatment of bronchial asthma with medium type and severe type can efficiently relieve clinical symptoms and signs,higher pulmonary ventilation function and life quality and have no increased risk of adverse effects.