CAJ | 학술논문

目的：：观察右美托咪定在开腹肝脏肿瘤切除手术患者全身麻醉中的有效性和安全性。方法：择期开腹肝脏肿瘤切除手术患者60例，年龄30～65岁，ASAⅠ～Ⅲ级，随机均分为两组，麻醉诱导和维持分别采用丙泊酚（P组）和右美托咪定（D组），同时均吸入七氟烷。观察和记录麻醉期间患者MAP和HR的变化，苏醒时间和术毕时出现的烦躁、瞻望等不良反应情况。结果：与麻醉前比较，P组MAP在气管插管前显著降低，气管插管后和拔管前显著升高（P＜0.05），D组MAP未有显著变化，麻醉诱导后D组HR明显减慢（P＜0.05），P组HR仅在气管插管后和拔管前显著增快（P＜0.05）,P组术毕2例患者出现术后躁动，D组未见明显不良反应。结论：右美托咪定用于开腹肝脏肿瘤切除手术患者，心率减慢，血压稳定，苏醒及时，术后躁动等不良反应少。
목적：：관찰우미탁미정재개복간장종류절제수술환자전신마취중적유효성화안전성。방법：택기개복간장종류절제수술환자60례，년령30～65세，ASAⅠ～Ⅲ급，수궤균분위량조，마취유도화유지분별채용병박분（P조）화우미탁미정（D조），동시균흡입칠불완。관찰화기록마취기간환자MAP화HR적변화，소성시간화술필시출현적번조、첨망등불량반응정황。결과：여마취전비교，P조MAP재기관삽관전현저강저，기관삽관후화발관전현저승고（P＜0.05），D조MAP미유현저변화，마취유도후D조HR명현감만（P＜0.05），P조HR부재기관삽관후화발관전현저증쾌（P＜0.05）,P조술필2례환자출현술후조동，D조미견명현불량반응。결론：우미탁미정용우개복간장종류절제수술환자，심솔감만，혈압은정，소성급시，술후조동등불량반응소。
Objective To observe the effects of dexmedetomidine efficacy and safety in open liver tumorresection operation in pa-tientswith generalanesthesia. Methods elective abdominal operation patients with liver tumorresectionin60 cases, age 30 ~65 years old, ASAI ~ IIIgrade, wererandomlydividedintotwo groups, anesthesia wasinducedandmaintained with propofolrespectively (groupP) and dexmedetomidine (groupD), andallofthemwereinhaled seven sevoflurane. Changesin MAPandHR patientsduring theobservationan-drecordingofanesthesia,adversereactions andirritability, andothercircumstances ofrecoverytimeand look attheendoftheoperation.Results compared with those beforeanesthesia, P group, MAP decreased significantly before tracheal intubation, after tracheal intubation and ex-tubationwere significantly higher (P<0.05), significant changes in group D MAP no, after induction of anesthesia in group D HR is significantly slower (P<0.05), P groupHR only after intubation andextubation before significantlyfaster (P<0.05),restless P groupafter-operation 2patients afteroperation,Dgrouphadnoobviousadversereaction.Conclusiondexmedetomidine for open liver tumorresection pa-tients, heartrate, bloodpressure stable, wakeup intime,postoperative agitation and other less adverse reaction.