广州医科大学学报
廣州醫科大學學報
엄주의과대학학보
Academic Journal of Guangzhou Medical College
2014年
5期
13-15
,共3页
曾碧丹%任海红%张文静%罗燕华%陈菲%邱少东
曾碧丹%任海紅%張文靜%囉燕華%陳菲%邱少東
증벽단%임해홍%장문정%라연화%진비%구소동
血糖%超声%SonoVue%透皮吸收
血糖%超聲%SonoVue%透皮吸收
혈당%초성%SonoVue%투피흡수
blood glucose%ultrasound%SonoVue%transdermal absorption
目的：：通过动物实验研究诊断超声联合微泡对葡萄糖透皮吸收的影响。方法：分对照组及实验组。对照组测定空腹血糖及与溶液接触6 min后血糖。实验组测定空腹血糖,并通过输液泵匀速注入SonoVue混悬液,测定与溶液接触6 min后,测实验兔血糖浓度,分析实验组6 min血糖浓度与对照组6min血糖浓度及实验兔空腹血糖浓度差异。结果：实验兔空腹血糖浓度约为(5.33±0.53)mmol/L,对照组6 min血糖浓度约为(5.40±0.50)mmol/L,实验组6 min血糖浓度约为(6.15±0.61)mmol/L,实验组6 min血糖浓度与对照组6 min血糖浓度及实验兔空腹血糖浓度差异有统计学意义,(P<0.05)。结论：诊断超声联合微泡可促进葡萄糖透皮吸收,其原理可能与SonoVue增强局部空化作用有关。
目的：：通過動物實驗研究診斷超聲聯閤微泡對葡萄糖透皮吸收的影響。方法：分對照組及實驗組。對照組測定空腹血糖及與溶液接觸6 min後血糖。實驗組測定空腹血糖,併通過輸液泵勻速註入SonoVue混懸液,測定與溶液接觸6 min後,測實驗兔血糖濃度,分析實驗組6 min血糖濃度與對照組6min血糖濃度及實驗兔空腹血糖濃度差異。結果：實驗兔空腹血糖濃度約為(5.33±0.53)mmol/L,對照組6 min血糖濃度約為(5.40±0.50)mmol/L,實驗組6 min血糖濃度約為(6.15±0.61)mmol/L,實驗組6 min血糖濃度與對照組6 min血糖濃度及實驗兔空腹血糖濃度差異有統計學意義,(P<0.05)。結論：診斷超聲聯閤微泡可促進葡萄糖透皮吸收,其原理可能與SonoVue增彊跼部空化作用有關。
목적：：통과동물실험연구진단초성연합미포대포도당투피흡수적영향。방법：분대조조급실험조。대조조측정공복혈당급여용액접촉6 min후혈당。실험조측정공복혈당,병통과수액빙균속주입SonoVue혼현액,측정여용액접촉6 min후,측실험토혈당농도,분석실험조6 min혈당농도여대조조6min혈당농도급실험토공복혈당농도차이。결과：실험토공복혈당농도약위(5.33±0.53)mmol/L,대조조6 min혈당농도약위(5.40±0.50)mmol/L,실험조6 min혈당농도약위(6.15±0.61)mmol/L,실험조6 min혈당농도여대조조6 min혈당농도급실험토공복혈당농도차이유통계학의의,(P<0.05)。결론：진단초성연합미포가촉진포도당투피흡수,기원리가능여SonoVue증강국부공화작용유관。
Objective: To investigate effects of diagnostic ultrasound combined with microbubble on the transdermal absorption of glucose by animal studies. Methods:A control group and an experimental group were included in the study.The control group was measure for levels of fasting blood glucose and blood glucose level at 6 min of dermal contact with glucose solution.The experimental group was measured for fasting blood glucose,then injected with SonoVue suspension by a constant-speed infusion pump before measured for the blood glucose level at 6 min of dermal contact with glucose solution. The differences between the 6 min blood glucose level and the fasting blood glucose was analyzed in the experimental and the control group.Results:Fasting blood glucose level of the experimental rabbits was (5.33±0.53) mmol/L.6 min blood glucose concentration of the control group was (5.40±0.50) mmol/L.6 min blood glucose concentration of the experimental group was about (6.15±0.61) mmol/L.And there were statistical differences in 6 min blood glucose levels between the experimental group and the control group,and between 6 min blood glucose levels and the fasting blood glucose level in either group of rabbits ( P<0. 05 ) . Conclusion:Diagnostic ultrasound combined with microbubble can promote transdermal absorption of glucose. The underlying mechanism may be associated with the effects of SonoVue enhanced local cavitation.
