广州医科大学学报
廣州醫科大學學報
엄주의과대학학보
Academic Journal of Guangzhou Medical College
2014年
5期
32-35
,共4页
梗阻性黄疸%肿瘤标志物%CA50%CA125%CA19-9%CEA%诊断
梗阻性黃疸%腫瘤標誌物%CA50%CA125%CA19-9%CEA%診斷
경조성황달%종류표지물%CA50%CA125%CA19-9%CEA%진단
obstructive jaundice%tumor markers%CA50,CA125,CA19-9,CEA%diagnosis
目的：：分析CA50、CA125、CA19-9和CEA在肿瘤性梗阻性黄疸鉴别诊断中的价值,为临床诊断提供参考依据。方法：选择2011年6月至2013年9月本院收治的86例梗阻性黄疸患者作为研究对象,根据患者病情分为良性疾病组( n＝49)、肿瘤组( n＝37),选取同时期40例门诊健康体检者作为对照组,检测三组对象的CA50、CA125、CA19-9和CEA水平并进行统计学分析。结果：肿瘤组CA125、CEA水平高于良性疾病组,CA50、CA125、CA19-9、CEA高于对照组( P<0.05)；肿瘤组各标志物和联合检测阳性率均高于良性疾病组和对照组(P<0.05)；联合检测敏感性、准确性为91.89％和94.59％,均高于肿瘤标志物单项检测(P<0.05)；术后肿瘤组患者 CA50、CA19-9、CA125、CEA水平均低于术前(P<0.05)。结论：CA50、CA125、CA19-9和CEA可作为肿瘤性梗阻性黄疸鉴别诊断的辅助指标,联合检测可提高诊断的准确性和敏感性。
目的：：分析CA50、CA125、CA19-9和CEA在腫瘤性梗阻性黃疸鑒彆診斷中的價值,為臨床診斷提供參攷依據。方法：選擇2011年6月至2013年9月本院收治的86例梗阻性黃疸患者作為研究對象,根據患者病情分為良性疾病組( n＝49)、腫瘤組( n＝37),選取同時期40例門診健康體檢者作為對照組,檢測三組對象的CA50、CA125、CA19-9和CEA水平併進行統計學分析。結果：腫瘤組CA125、CEA水平高于良性疾病組,CA50、CA125、CA19-9、CEA高于對照組( P<0.05)；腫瘤組各標誌物和聯閤檢測暘性率均高于良性疾病組和對照組(P<0.05)；聯閤檢測敏感性、準確性為91.89％和94.59％,均高于腫瘤標誌物單項檢測(P<0.05)；術後腫瘤組患者 CA50、CA19-9、CA125、CEA水平均低于術前(P<0.05)。結論：CA50、CA125、CA19-9和CEA可作為腫瘤性梗阻性黃疸鑒彆診斷的輔助指標,聯閤檢測可提高診斷的準確性和敏感性。
목적：：분석CA50、CA125、CA19-9화CEA재종류성경조성황달감별진단중적개치,위림상진단제공삼고의거。방법：선택2011년6월지2013년9월본원수치적86례경조성황달환자작위연구대상,근거환자병정분위량성질병조( n＝49)、종류조( n＝37),선취동시기40례문진건강체검자작위대조조,검측삼조대상적CA50、CA125、CA19-9화CEA수평병진행통계학분석。결과：종류조CA125、CEA수평고우량성질병조,CA50、CA125、CA19-9、CEA고우대조조( P<0.05)；종류조각표지물화연합검측양성솔균고우량성질병조화대조조(P<0.05)；연합검측민감성、준학성위91.89％화94.59％,균고우종류표지물단항검측(P<0.05)；술후종류조환자 CA50、CA19-9、CA125、CEA수평균저우술전(P<0.05)。결론：CA50、CA125、CA19-9화CEA가작위종류성경조성황달감별진단적보조지표,연합검측가제고진단적준학성화민감성。
Objective:To investigate the value of combined detection of CA50,CA125,CA19-9 and CEA in differential diagnosis of malignant obstructive jaundice,and to provide evidence for clinical diagnosis. Methods:Eighty-six patients with obstructive jaundice admitted to our hospital between June 2011 and September 2013 were selected and divided into benign disease group (n=49) and tumor group (n=37).Forty healthy subjects were selected as the control group.The CA50,CA125,CA19-9 and CEA levels of the three groups were detected and statistically analyzed. Results:Of the tumor group, CA125 and CEA levels were higher than those in benign disease group, and CA50, CA125, CA19-9, CEA levels were higher than those of the control group, and the differences were statistically significant ( P<0.05);the positive rates of tumor markers detected individually or in combination were higher in the tumor group than those in benign disease group or the control group, and the differences were statistically significant (P<0.05); the sensitivity and the accuracy of combined detection were 91.89% and 94.59% respectively,which were higher than those of individual detection of tumor markers,and the differences were statistically significant ( P<0. 05 ) . After operation, the CA50, CA19-9, CA125, CEA levels in patients of the tumor group were lower than those before operation,and the differences were statistically significant (P<0.05).Conclusion:CA50,CA125,CA19-9 and CEA can be used as auxiliary parameters in diagnosing tumor among patients with obstructive jaundice.Combined detection can also improve diagnostic accuracy and sensitivity.
