CAJ | 학술논문

目的：探讨促性腺激素释放激素激动剂（GnRHa）及避孕药物预防女性卵巢生殖细胞肿瘤化疗患者卵巢损伤的临床疗效。方法收集女性生殖细胞肿瘤60例患者资料，将患者随机分为3组，各20例。对照组患者给予常规化疗， GnRHa 组患者在常规化疗的基础上肌内注射醋酸曲普瑞林，避孕药物组在化疗的基础上口服炔雌醇环丙孕酮片，在化疗过程中及停药后，定期监测患者的月经情况、排卵情况。结果对照组患者的排卵率、月经恢复率均明显低于GnRHa组及避孕药物组，且对照组患者的卵巢功能早衰发生率明显高于GnRHa组及避孕药物组；GnRHa组患者的排卵率、月经恢复率均明显优于对照组和避孕药物组，且GnRHa组患者的卵巢功能早衰发生率明显低于对照组和避孕药物组，差异均有统计学意义（均P＜0.05）。结论 GnRHa及避孕药物均可明显降低年轻女性卵巢生殖细胞肿瘤化疗所致卵巢功能损伤，保障患者预后及生活质量，但GnRHa作用效果更优。
목적：탐토촉성선격소석방격소격동제（GnRHa）급피잉약물예방녀성란소생식세포종류화료환자란소손상적림상료효。방법수집녀성생식세포종류60례환자자료，장환자수궤분위3조，각20례。대조조환자급여상규화료， GnRHa 조환자재상규화료적기출상기내주사작산곡보서림，피잉약물조재화료적기출상구복결자순배병잉동편，재화료과정중급정약후，정기감측환자적월경정황、배란정황。결과대조조환자적배란솔、월경회복솔균명현저우GnRHa조급피잉약물조，차대조조환자적란소공능조쇠발생솔명현고우GnRHa조급피잉약물조；GnRHa조환자적배란솔、월경회복솔균명현우우대조조화피잉약물조，차GnRHa조환자적란소공능조쇠발생솔명현저우대조조화피잉약물조，차이균유통계학의의（균P＜0.05）。결론 GnRHa급피잉약물균가명현강저년경녀성란소생식세포종류화료소치란소공능손상，보장환자예후급생활질량，단GnRHa작용효과경우。
Objective To explore the gonadotropin-releasing hormone agonist(GnRHa)and contraceptives protect women ovarian germ cel tumor clinical curative effect of chemotherapy in patients with ovarian damage.Methods Colected 60 cases of female patients with germ cel tumors,were randomly divided into 3 groups,20 cases in each.Patients in control group were treated with conventional chemotherapy,patients in group GnRHa intramuscular injection on the basis of conventional chemotherapy Triptorelin acetate for injection.The pil in the chemotherapy group based on the use of Ethinylestradiol and Cyproterone Acetate Tablets,during chemotherapy and after stopping drug,regular monitoring of menstruation,the ovulation in patients with.Results Patients in the control group,the rate of ovulation menstrual recovery rate was significantly lower than GnRHa group and the pil group,and control group of patients with premature ovarian failure was significantly higher than that in group GnRHa and group GnRHa patients pil;ovulation rate,menstrual recovery rate was significantly better than the control group and the pil group,and GnRHa group of patients with premature ovarian failure incidence was significantly lower than that of the control group and the pil group;the differences were statisticaly significant(P<0.05).Conclusion GnRHa and the pil could significantly decrease the ovarian function damage induced by chemotherapy,prognosis and life quality of patients with security,but the GnRHa effect better.