现代农药
現代農藥
현대농약
MODERN AGROCHEMICALS
2015年
2期
4-7
,共4页
于康平%李泽方%尹洪波%刘慕兰%李惠
于康平%李澤方%尹洪波%劉慕蘭%李惠
우강평%리택방%윤홍파%류모란%리혜
啶酰菌胺%同系物%合成%Friedel-Crafts烷基化反应%杀菌活性
啶酰菌胺%同繫物%閤成%Friedel-Crafts烷基化反應%殺菌活性
정선균알%동계물%합성%Friedel-Crafts완기화반응%살균활성
boscalid%analog%synthesis%Friedel-Crafts alkylation%fungicidal activity
以4-卤联苯为起始原料,通过Friedel-Crafts烷基化反应、硝化、还原、缩合及Friedel-Crafts逆烷基化等反应,建立了一种杀菌剂啶酰菌胺及其同系物的合成新方法,并制备了啶酰菌胺及7个同系物,其结构经过1H NMR、质谱和红外等确认。初步杀菌活性结果表明,在50 mg/L质量浓度下,目标化合物对部分病原菌表现出良好的活性。
以4-滷聯苯為起始原料,通過Friedel-Crafts烷基化反應、硝化、還原、縮閤及Friedel-Crafts逆烷基化等反應,建立瞭一種殺菌劑啶酰菌胺及其同繫物的閤成新方法,併製備瞭啶酰菌胺及7箇同繫物,其結構經過1H NMR、質譜和紅外等確認。初步殺菌活性結果錶明,在50 mg/L質量濃度下,目標化閤物對部分病原菌錶現齣良好的活性。
이4-서련분위기시원료,통과Friedel-Crafts완기화반응、초화、환원、축합급Friedel-Crafts역완기화등반응,건립료일충살균제정선균알급기동계물적합성신방법,병제비료정선균알급7개동계물,기결구경과1H NMR、질보화홍외등학인。초보살균활성결과표명,재50 mg/L질량농도하,목표화합물대부분병원균표현출량호적활성。
A novel method was employed for preparing boscalid and its alkyl analogs via Friedel-Crafts alkylation, nitration, reduction, condensation, and reverse Friedel-Crafts alkylation from 4-halobiphenyl. Then boscalid and seven analogs were confirmed by 1H NMR, mass spectrum and IR analysis. Preliminary bioassays indicated that the target compounds were effective to some of tested pathogens at 50 mg/L.