CAJ | 학술논문

目的探讨单独及联合使用氯沙坦和硝苯地平治疗老年原发性高血压的临床效果,为临床用药提供依据.方法将本院收治的老年原发性高血压患者354例随机分为氯沙坦治疗组(A组)、硝苯地平治疗组(B组)和氯沙坦联合硝苯地平治疗组(C组).其中A组按病情轻重给予氯沙坦钾片50 ～ 100mg/d,B组给予硝苯地平控释片30 mg/d,C组联合使用氯沙坦钾片和硝苯地平控释片,用量与A组和B组相同,每周测量两次血压,持续4周.根据实际疗效调整服药剂量并记录不良药物反应和血压值.疗程结束后统计并分析数据.结果单独用药组服用氯沙坦钾片和硝苯地平控释片4周后总效率分别达到64.1％和59.0％,而联合用药组总效率达到82.5％,与单独用药比较具有显著差异(x2=5.204,P=0.027;x2=5.734,P=0.019).降压效果对比,单独用药组之间对比差异无统计学意义(P＞0.05),而C组与A组比较差异显著(x2=4.233,P=0.016);C组与B组比较差异显著(x2=7.253,P=0.008).药物副作用方面氯沙坦组发生率为7.7％,硝苯地平组为15.4％,联合用药组为17.5％,单一用药组间不良反应具有显著差异(P＜0.05),而单一使用硝苯地平组和联合用药组则无显著差异(P＞0.05).结论单一使用氯沙坦和硝苯地平均能在一定程度上降低血压,而联合使用两种药物则能明显提升疗效,且用药合理,安全性高.
목적 탐토단독급연합사용록사탄화초분지평치료노년원발성고혈압적림상효과,위림상용약제공의거.방법 장본원수치적노년원발성고혈압환자354례수궤분위록사탄치료조(A조)、초분지평치료조(B조)화록사탄연합초분지평치료조(C조).기중A조안병정경중급여록사탄갑편50 ～ 100mg/d,B조급여초분지평공석편30 mg/d,C조연합사용록사탄갑편화초분지평공석편,용량여A조화B조상동,매주측량량차혈압,지속4주.근거실제료효조정복약제량병기록불량약물반응화혈압치.료정결속후통계병분석수거.결과 단독용약조복용록사탄갑편화초분지평공석편4주후총효솔분별체도64.1％화59.0％,이연합용약조총효솔체도82.5％,여단독용약비교구유현저차이(x2=5.204,P=0.027;x2=5.734,P=0.019).강압효과대비,단독용약조지간대비차이무통계학의의(P＞0.05),이C조여A조비교차이현저(x2=4.233,P=0.016);C조여B조비교차이현저(x2=7.253,P=0.008).약물부작용방면록사탄조발생솔위7.7％,초분지평조위15.4％,연합용약조위17.5％,단일용약조간불량반응구유현저차이(P＜0.05),이단일사용초분지평조화연합용약조칙무현저차이(P＞0.05).결론 단일사용록사탄화초분지평균능재일정정도상강저혈압,이연합사용량충약물칙능명현제승료효,차용약합리,안전성고.
Objective To explore the clinical effect of single and combined use of losartan and nifedipine in the treatment of elderly patients with essential hypertension and provide evidence for clinical use of drugs.Methods In our hospital in elderly patients with essential hypertension 354 cases were randomly divided into losartan treatment group (group A),nifedipine treatment group (group B) and losartan combined with nifedipine treatment group (group C),in which group A according to the severity of giving Losartan Potassium Tablets 50 100 mg/d,group B given Nifedipine Controlled Realease Tablets 30 mg/d,group C with the use of Losartan Potassium Tablets and Nifedipine Controlled Realease Tablets,the dosage of Group C were the same with group A and group B,measured blood pressure two times in every week,for 4 weeks.According to the actual effect to adjust drug dosage and to record the adverse drug reaction and blood pressure value.After the end of treatment and statistical analysis of data.Results The results of single drug group took Losartan Potassium Tablets and Nifedipine Controlled RealeaseTablets after 4 weeks,total efficiency reached 64.1％ and 59.0％,and the total efficiency of the combined treatment group reached to 82.5％,compared with the single drug has significant difference (x 2=5.204,P =0.027; x 2=5.734,P =0.019).The antihypertensive effect of contrast between the monotherapy group contrast difference was not statistically significant (P ＞0.05) and group C compared with group A had significant difference (x 2=4.233,P ＞0.016) compared with group B and group C significantly (x 2=7.253,P =0.008).Drug side effects of losartan group,the incidence rate was 7.7％,nifedipine group was 15.4％ and the combined treatment group was 17.5％,single drug adverse reaction has significant difference between groups (P ＞0.05) and only use the nifedipine group and combination group with no significant difference (P ＞0.05).Conclusion The single use of losartan and nifedipine can reduce the blood pressure to a certain extent,and the combined use of the two drugs can significantly improve the curative effect,and using drugs was ratianal and high safty.