CAJ | 학술논문

儿童葡萄膜炎占所有葡萄膜炎的5％～10％,多数起病隐匿、病程迁延,常合并多种眼部并发症.儿童葡萄膜炎多为非感染性,其中绝大多数为特发性,最常见的全身病因为幼年特发性关节炎.儿童葡萄膜炎治疗棘手,常用药物为糖皮质激素、抗代谢药、T细胞抑制剂.近年来生物制剂的使用为儿童非感染性葡萄膜炎的治疗提供了新方法.玻璃体腔植入糖皮质激素缓释装置可长时间控制眼内炎症,但在儿童中使用的安全性及有效性仍待进一步研究.
인동포도막염점소유포도막염적5％～10％,다수기병은닉、병정천연,상합병다충안부병발증.인동포도막염다위비감염성,기중절대다수위특발성,최상견적전신병인위유년특발성관절염.인동포도막염치료극수,상용약물위당피질격소、항대사약、T세포억제제.근년래생물제제적사용위인동비감염성포도막염적치료제공료신방법.파리체강식입당피질격소완석장치가장시간공제안내염증,단재인동중사용적안전성급유효성잉대진일보연구.
Pediatric uveitis is accounting for 5％～ 10％ of all the uveitis.Most individuals have an insidious onset and persistent duration,ocular complications are common.Most pediatric uveitis are noninfectious and idiopathic,the most common etiologic diagnosis is juvenile idiopathic arthritis.Treatment of pediatric uveitis is tough,the mainstays of therapy include corticosteroids,antimetabolites,and T-cell inhibitors.In the last decade,biologic agents provide us new methods for treating pediatric uveitis.Intravitreal corticosteroid delivery devices have enhanced our ability to provide longer-lasting local disease control,but there are very limited data showing the efficacy and safety in children.