CAJ | 학술논문

目的：观察维持性泼尼松治疗视神经脊髓炎（neuromyelitis optica，NMO）的疗效及安全性。方法对17例复发型NMO患者进行随访，观察在维持性泼尼松治疗前后，患者的扩展残疾状态量表（expanded disability status scale，EDSS）评分、年复发率的变化以及治疗期间出现的不良反应。结果经维持性泼尼松治疗后，患者的EDSS评分较治疗前改善[(3.09±0.85) vs.(4.06±0.80)]，差异有统计学意义（P<0.05）；年复发率较治疗前明显下降[(0.34±0.31)次/年vs.(1.51±0.57)次/年]，差异有统计学意义（P<0.005）；但不同剂量泼尼松对于年复发率降低水平的影响差异无统计学意义。随访期间无严重不良反应出现。结论维持性泼尼松治疗能有效降低NMO患者的年复发率，并改善其神经功能缺失情况，有较好的耐受性。
목적：관찰유지성발니송치료시신경척수염（neuromyelitis optica，NMO）적료효급안전성。방법대17례복발형NMO환자진행수방，관찰재유지성발니송치료전후，환자적확전잔질상태량표（expanded disability status scale，EDSS）평분、년복발솔적변화이급치료기간출현적불량반응。결과경유지성발니송치료후，환자적EDSS평분교치료전개선[(3.09±0.85) vs.(4.06±0.80)]，차이유통계학의의（P<0.05）；년복발솔교치료전명현하강[(0.34±0.31)차/년vs.(1.51±0.57)차/년]，차이유통계학의의（P<0.005）；단불동제량발니송대우년복발솔강저수평적영향차이무통계학의의。수방기간무엄중불량반응출현。결론유지성발니송치료능유효강저NMO환자적년복발솔，병개선기신경공능결실정황，유교호적내수성。
Objective To evaluate the efficacy and safety of oral prednisone in patients with relapsing neuromyeli?tis optica. Methods Seventeen patients with relapsing neuromyelitis optica receiving long-term oral prednisone had been followed. The Expanded Disability Status Scale (EDSS) and annualized relapse rates were used to evaluate curative effect. Results During long-term oral prednisone treatment, patients had a significant reduction in the EDSS [(3.09 ± 0.85) vs. (4.06 ± 0.80), P<0.05] and the median annualized relapse rate was significant reduced [(0.34 ± 0.31) vs. (1.51 ± 0.57), P<0.005]. But the effect of different dosage of prednisone on annualized relapse rates was not different. No severe adverse re?actions were observed. Conclusions Treatment with long-term oral prednisone in patients with NMO significantly reduces relapse rates, improves neurological function and the treatment was well-tolerated.