CAJ | 학술논문

目的探讨高原人体运动前后血流动力学的变化及高压氧预处理(hyperbaric oxygen preconditioning,HBOP)的影响,为改善高原劳动能力寻求新的措施.方法 6名由平原入伍进驻到海拔3800m高原地区6～24个月的健康男性战士自愿参与实验研究,用心-血管动力监控仪分别对受试对象在HBOP前和预处理5、7d后安静时,运动5 min以及运动后恢复3 min时的每搏输出量(stroke volume,SV)、左室射血时间(left ventricular ejection time,LVET)、心率(heart rate,HR)、逐次心跳间期(inter-beat interval,IBI)和心输出量(cardiac output,CO)等血流动力学指标进行记录分析.结果 HBOP7 d体力负荷5 min时的SV[(110.32±11.99) ml]较同状态下无HBOP的对照值[(85.08±23.48) ml]显著增加,差异具有统计学意义(P＜0.05);HBOP5 d运动后恢复3 min时LVET[(267.24±13.62) ms]较对照组[(243.79±11.56)ms]显著延长,差异具有统计学意义(P＜0.05);同时,HBOP后IBI延长、HR减慢,CO有增加的趋势,但与对照值比较均不具有统计学意义(均P＞0.05);经HBOP 7 d后各指标较HBOP5 d时未见显著变化(P＞0.05).结论机体在高原低氧环境下体力负荷时心肌收缩力降低,心脏泵血功能受到抑制,HBOP能通过改善机体血流动力学提高心脏储备能力,增强高原缺氧环境下的心-血管功能,从而改善高原战士的劳动能力,而且经HBOP5 d即可达到改善血流动力学的目的,效果与HBOP7 d差异无统计学意义.
목적 탐토고원인체운동전후혈류동역학적변화급고압양예처리(hyperbaric oxygen preconditioning,HBOP)적영향,위개선고원노동능력심구신적조시.방법 6명유평원입오진주도해발3800m고원지구6～24개월적건강남성전사자원삼여실험연구,용심-혈관동력감공의분별대수시대상재HBOP전화예처리5、7d후안정시,운동5 min이급운동후회복3 min시적매박수출량(stroke volume,SV)、좌실사혈시간(left ventricular ejection time,LVET)、심솔(heart rate,HR)、축차심도간기(inter-beat interval,IBI)화심수출량(cardiac output,CO)등혈류동역학지표진행기록분석.결과 HBOP7 d체력부하5 min시적SV[(110.32±11.99) ml]교동상태하무HBOP적대조치[(85.08±23.48) ml]현저증가,차이구유통계학의의(P＜0.05);HBOP5 d운동후회복3 min시LVET[(267.24±13.62) ms]교대조조[(243.79±11.56)ms]현저연장,차이구유통계학의의(P＜0.05);동시,HBOP후IBI연장、HR감만,CO유증가적추세,단여대조치비교균불구유통계학의의(균P＞0.05);경HBOP 7 d후각지표교HBOP5 d시미견현저변화(P＞0.05).결론 궤체재고원저양배경하체력부하시심기수축력강저,심장빙혈공능수도억제,HBOP능통과개선궤체혈류동역학제고심장저비능력,증강고원결양배경하적심-혈관공능,종이개선고원전사적노동능력,이차경HBOP5 d즉가체도개선혈류동역학적목적,효과여HBOP7 d차이무통계학의의.
Objective To investigate changes in hemodynamics both before and after physical exercise and the protective effects of hyperbaric oxygen preconditioning (HBOP) on the soldiers,so as to find out new measures for enhancement of human physical performance at high plateau regions.Methods Six healthy male soldiers who used to live in the plain region,joined the army,and moved to the high plateau at an altitude of 3 800 m 6 to 24 months ago were voluntarily enrolled for our study.Such hemodynamic parameters as stroke volume (SV),left ventricular ejection time (LVET),heart rate (HR),inter-beat interval (IBI) and cardiac output (CO) before HBOP and after 5-day and 7-day HBOP and at rest,as well as at 5-minute exercise and 3 minutes after exercise,were recorded and analyzed by using the cardiovascular dynamic monitor.Results The stroke volume detected at 5-minute physical load following 7-day HBOP was significantly increased[(110.32 ± 11.99)ml],as compared with the control value[(85.08 ± 23.48)ml],with statistical significance (P ＜ 0.05),while left ventricular ejection time was significantly prolonged [(267.24 ± 13.62) ml],as compared with the control value[(243.79 ± 11.56) ml],also with statistical significance (P ＜ 0.05).inter-beat interval was prolonged,HR decreased and CO increased,following HBOP,but there was statistical significance,when comparisons were made with those of the control values (P ＜ 0.05).No significant changes in the levels of various parameters could be seen,after 7-day HBOP,as compared with the levels of the parameters after 5-day HBOP.Conclusions Myocardial contraction was decreased at acute hypoxia and with physical load and cardiac output was also obviously reduced.HBOP could increase potential cardiac output through improvement of hemodynamics and enhance cardiovascular function at acute hypoxia,thus increasing the physical performance of the soldiers at high plateau regions.Furthermore,5-day HBOP could achieve the goal of improving hemodynamics.