CAJ | 학술논문

目的探讨2014年1月发生在驻浙、沪某部队新兵营的一起成人腺病毒B组7型聚集性感染疫情的临床特征.方法对集中发病的70例患者的临床症状、体征、胸部CT、实验室检查进行统计分析,采集咽拭子,荧光定量PCR检测病毒核酸以查找病原.结果入院的70例患者中,发热70例(100.0％)、咳嗽58例(82.9％)、咳痰51例(72.9％)、咽痛43例(61.4％).所有患者均表现为咽喉部黏膜充血、咽后壁广泛卵圆形滤泡伴线样充血.扁桃体肿大54例(77.1％),46例(65.7％)患者可见扁桃体被覆白色分泌物,咽部淋巴滤泡增生58例(82.9％).51例(72.9％)患者肺部影像学异常,肺纹理增粗模糊、肺间质炎、肺实质浆液性渗出较常见.54份咽拭子标本中,34份(63.0％)分离出B组7型腺病毒株.70例患者全部治愈.结论腺病毒B组7型临床特征有别于其他型病毒株,传染力强,在特殊群体易致聚集性发病.早发现、早干预,可控制疫情蔓延.
목적 탐토2014년1월발생재주절、호모부대신병영적일기성인선병독B조7형취집성감염역정적림상특정.방법 대집중발병적70례환자적림상증상、체정、흉부CT、실험실검사진행통계분석,채집인식자,형광정량PCR검측병독핵산이사조병원.결과 입원적70례환자중,발열70례(100.0％)、해수58례(82.9％)、해담51례(72.9％)、인통43례(61.4％).소유환자균표현위인후부점막충혈、인후벽엄범란원형려포반선양충혈.편도체종대54례(77.1％),46례(65.7％)환자가견편도체피복백색분비물,인부림파려포증생58례(82.9％).51례(72.9％)환자폐부영상학이상,폐문리증조모호、폐간질염、폐실질장액성삼출교상견.54빈인식자표본중,34빈(63.0％)분리출B조7형선병독주.70례환자전부치유.결론 선병독B조7형림상특정유별우기타형병독주,전염력강,재특수군체역치취집성발병.조발현、조간예,가공제역정만연.
Objective To investigate the clinical characteristics of a clustering infection caused by human adenovirus-B type 7 (HAdV-B7) which occurred in one military camp located at the southeastern coastal region in January 2014.Methods All clinical characteristics of the 70 patients were collected for analysis,including clinical symptoms and signs,chest computer tomography (CT) scans and laboratory results.Throat swabs were collected and real time polymerase chain reaction (RT-PCR) was performed to detect viral nucleotide.Results The prominent symptoms of these patients with HAdV-B7 infection included fever (100.0％,70/70),cough (82.9％,58/70),productive cough (72.9％,51/70) and sore throat (61.4％,43/70).All patients showed posterior pharyngeal wall linear congestion with ovoid follicle.Fifty-four (77.1 ％) patients had enlarged tonsils and 46 (65.7 ％) patients had tonsils covered by white secretions.Fifty-eight (82.9 ％) patients had pharyngeal follicular hyperplasia.Fifty-one (72.9 ％) patients had abnormalities on chest radiograph,including lung-marking fuzzy,pulmonary interstitial inflammation and parenchymal serous exudation.Of the 54 throat swabs from patients,34(63.0％) were identified as HAdV-B7.All patients were cured.Conclusions The clinical features of patients with HAdV-B7 infection are different from other viral infection.HAdV-B7 is easy to cause clustering infection in particular populations.Early detection and early intervention are needed to avoid exacerbation and transmission.