CAJ | 학술논문

目的：探讨尼麦角林治疗老年慢性脑血管功能不全的临床效果。方法采用随机数表法将本院神经内科2012年7月至2014年7月收治的162例老年慢性脑血管功能不全患者分为尼麦角林组和常规组，每组各81例。常规组患者采用常规治疗方法，尼麦角林组患者在常规治疗基础上加用尼麦角林。比较两组患者治疗的临床效果。结果治疗前，两组患者大脑中动脉、椎动脉的彩色多普勒超声检测指标[舒张期末流速（Vd）、收缩期峰流速（Vs）、阻力指数（RI）、搏动指数（PI）]比较差异均无显著性（P＞0.05）；治疗后12周，两组患者的Vd、Vs、RI、PI较组内治疗前明显好转，差异均具有显著性（P＜0.05），且尼麦角林组患者的Vd、Vs、RI、PI优于常规组，差异具有显著性（P＜0.05）。治疗前两组患者的简易精神状态检查量表（MMSE）评分比较差异无显著性（P＞0.05）；治疗后两组患者MMSE评分较治疗前均显著提高（P＜0.05），且尼麦角林组患者的MMSE评分[（24.5±1.3）分]显著高于常规组[（22.9±1.5）分]，差异具有显著性（P＜0.05）。治疗后12周，尼麦角林组患者治疗总有效率（91.36%）高于常规组（76.54%），差异具有显著性（P＜0.05）。结论尼麦角林可以改善老年慢性脑血管功能不全患者的临床症状及大脑血管血流情况，同时可以显著提高临床治疗效果。
목적：탐토니맥각림치료노년만성뇌혈관공능불전적림상효과。방법채용수궤수표법장본원신경내과2012년7월지2014년7월수치적162례노년만성뇌혈관공능불전환자분위니맥각림조화상규조，매조각81례。상규조환자채용상규치료방법，니맥각림조환자재상규치료기출상가용니맥각림。비교량조환자치료적림상효과。결과치료전，량조환자대뇌중동맥、추동맥적채색다보륵초성검측지표[서장기말류속（Vd）、수축기봉류속（Vs）、조력지수（RI）、박동지수（PI）]비교차이균무현저성（P＞0.05）；치료후12주，량조환자적Vd、Vs、RI、PI교조내치료전명현호전，차이균구유현저성（P＜0.05），차니맥각림조환자적Vd、Vs、RI、PI우우상규조，차이구유현저성（P＜0.05）。치료전량조환자적간역정신상태검사량표（MMSE）평분비교차이무현저성（P＞0.05）；치료후량조환자MMSE평분교치료전균현저제고（P＜0.05），차니맥각림조환자적MMSE평분[（24.5±1.3）분]현저고우상규조[（22.9±1.5）분]，차이구유현저성（P＜0.05）。치료후12주，니맥각림조환자치료총유효솔（91.36%）고우상규조（76.54%），차이구유현저성（P＜0.05）。결론니맥각림가이개선노년만성뇌혈관공능불전환자적림상증상급대뇌혈관혈류정황，동시가이현저제고림상치료효과。
Objective To investigate the clinical effect of nicergoline in treatment of elderly patients with chronic cerebrospinal venous insufficiency. Method Used random number table method to selected 162 cases of elderly patients with chronic cerebrovascular venous insufficiency from July 2012 to July 2014 in our hospital as research objects, they were divided into nicergoline group and routine group, 81 cases in each group. Routine group patients were treated with conventional methods, on the basis of conventional treatment, nicergoline group patients were treated with nicergoline. Clinical effects of the two groups were compared. Result Before treatment, the index [color Doppler ultrasound detection of vertebral artery and middle cerebral artery, the end diastolic velocity (Vd), peak systolic velocity (Vs), resistance index (RI), pulsatility index (PI)] were not signiifcant different (P>0.05);12 weeks after treatment, Vd, Vs, RI, PI of the two groups patients were signiifcantly improved than before treatment, the difference was signiifcant (P<0.05), and Vd, Vs, RI, PI of nicergoline group patients were superior to control group, the difference was signiifcant (P<0.05). MMSE scores of the two groups patients before treatment were not signiifcant different (P > 0.05);after treatment, MMSE scores of the two groups patients were signiifcantly increased than before treatment (P < 0.05), and MMSE scores of nicergoline group was (24.5±1.3) points, signiifcantly higher than routine group [(22.9±1.5) points], the difference was signiifcant (P<0.05). 12 weeks after treatment, total effective rate of nicergoline group was 91.36%, signiifcantly higher than routine group (76.54%), the difference was signiifcant (P<0.05). Conclusion Nicergoline can improve patients with elderly chronic cerebrospinal venous insufifciency clinical symptoms and brain blood lfows, and can signiifcantly improve the clinical treatment effect.