CAJ | 학술논문

目的：探讨乌司他丁对预防烧伤患者早期心肌损害的应用价值。方法将2013年4月~2014年4月我院收治的52例烧伤患者患者随机分为观察组和对照组，观察组给予常规对症治疗+乌司他丁，对照组给予常规对症治疗，检查两组患者第2、4、6天时的血浆心肌肌钙蛋白（cTnI）含量及血浆CKMB活性变化情况，并进行统计学分析比较。结果对照组患者的血浆cTnI含量在伤后逐渐升高在第4天时达到峰值，第7天稍降低，但仍明显高于正常值，而观察组患者血浆cTnI含量在各时间点的含量均显著低于对照组（ P＜0.05）。对照组患者伤后血浆CKMB活性逐渐升高，第4天时达到峰值，第7天有所降低，但仍高于正常值，而观察组在第2、4天时的血浆CKMB活性变化程度显著低于对照组，第7天时低于正常值（P＜0.01）。结论乌司他丁用于预防烧伤患者早期心肌损害的疗效显著，能有效降低心肌损害，值得临床推广。
목적：탐토오사타정대예방소상환자조기심기손해적응용개치。방법장2013년4월~2014년4월아원수치적52례소상환자환자수궤분위관찰조화대조조，관찰조급여상규대증치료+오사타정，대조조급여상규대증치료，검사량조환자제2、4、6천시적혈장심기기개단백（cTnI）함량급혈장CKMB활성변화정황，병진행통계학분석비교。결과대조조환자적혈장cTnI함량재상후축점승고재제4천시체도봉치，제7천초강저，단잉명현고우정상치，이관찰조환자혈장cTnI함량재각시간점적함량균현저저우대조조（ P＜0.05）。대조조환자상후혈장CKMB활성축점승고，제4천시체도봉치，제7천유소강저，단잉고우정상치，이관찰조재제2、4천시적혈장CKMB활성변화정도현저저우대조조，제7천시저우정상치（P＜0.01）。결론오사타정용우예방소상환자조기심기손해적료효현저，능유효강저심기손해，치득림상추엄。
Objective To explore the application value of ulinastatin for prevention of early myocardial damage in burn patients. Methods 52 burn patients treated in our hospital from April 2013 to April 2014 were selected and randomly divided into observation group and control group. The patients in the observation group were given routine symptomatic treatment combined with ulinastatin while the patients in the control group were given routine symptomatic treatment. The content of plasma cardiac troponin (cTnI)and changes of activity of plasma CKMB in patients in two groups were checked on the second, fourth and sixth day and the statistical analysis and comparison were carried out. Results The content of plasma cardiac troponin (cTnI) and changes of activity of plasma CKMB in patients in the control group after the burn increased gradually and reached the peak on fourth day, and on the seventh day decreased slightly, but were still higher than normal value while the content of plasma cTnI in the patients in the observation group at different time points were significantly lower than those of the control group(P < 0.05). The activity of plasma CKMB in patients in control group increased gradually after the burn, and reached the peak on fourth day, and on the seventh days decreased, but was still higher than the normal value. But the changes of the activity of plasma CKMB in the patients in the observation group was significantly lower than that of control group on the second and seventh day, and were lower than normal value on the seventh day (P<0.01). Conclusion The clinical effect of ulinastatin for preventive effect of early myocardial damage in burn patients is significant and can effectively reduce the myocardial damage. This method is worth the clinical promotion.