中国医药科学
中國醫藥科學
중국의약과학
CHINA MEDICINE AND PHARMACY
2015年
6期
41-43,46
,共4页
门冬胰岛素%甘精胰岛素%2型糖尿病%疗效%胰腺功能
門鼕胰島素%甘精胰島素%2型糖尿病%療效%胰腺功能
문동이도소%감정이도소%2형당뇨병%료효%이선공능
Insulin aspart%Glargine%Type 2 diabetes%Efficacy%Pancreatic function
目的：探讨门冬胰岛素联合甘精胰岛素治疗2型糖尿病的疗效优势。方法选取2012年1月～2014年6月住院的68例2型糖尿病患者，随机分为门冬胰岛素联合甘精胰岛素组（实验组）和胰岛素泵组（对照组），均为34例，两组均接受正规的糖尿病饮食、运动指导及其他教育，生活作息时间及治疗规律。实验组的所有患者均予以门冬胰岛素（早、中、晚餐前，即刻皮下注射，诺和锐）+甘精胰岛素（晚睡前，皮下注射，来得时）治疗；对照组的所有患者均予以胰岛素泵持续皮下注射门冬胰岛素，两组患者均观察每日空腹血糖、3餐餐后2h血糖、晚10时血糖、空腹C肽、空腹淀粉酶、空腹脂肪酶、日血糖波动情况、日胰岛素用量、低血糖例数、体质指数、治疗达标时间及治疗费用。结果各组治疗前后的血糖控制情况、空腹C肽、空腹淀粉酶、空腹脂肪酶这些指标差异均有统计学意义（P＜0.05），体质指数差异无统计学意义（P＞0.05）；两组的日胰岛素用量、日血糖波动情况差异无统计学意义（P＞0.05）；实验组较对照组的治疗费用低，低血糖例数多（P＜0.05），但达标所需时间长（P＜0.05）。结论门冬胰岛素联合甘精胰岛素治疗的低血糖发生率高、达标时间长，但费用低，适用于基层医院及经济困难的患者，值得推广。
目的：探討門鼕胰島素聯閤甘精胰島素治療2型糖尿病的療效優勢。方法選取2012年1月～2014年6月住院的68例2型糖尿病患者，隨機分為門鼕胰島素聯閤甘精胰島素組（實驗組）和胰島素泵組（對照組），均為34例，兩組均接受正規的糖尿病飲食、運動指導及其他教育，生活作息時間及治療規律。實驗組的所有患者均予以門鼕胰島素（早、中、晚餐前，即刻皮下註射，諾和銳）+甘精胰島素（晚睡前，皮下註射，來得時）治療；對照組的所有患者均予以胰島素泵持續皮下註射門鼕胰島素，兩組患者均觀察每日空腹血糖、3餐餐後2h血糖、晚10時血糖、空腹C肽、空腹澱粉酶、空腹脂肪酶、日血糖波動情況、日胰島素用量、低血糖例數、體質指數、治療達標時間及治療費用。結果各組治療前後的血糖控製情況、空腹C肽、空腹澱粉酶、空腹脂肪酶這些指標差異均有統計學意義（P＜0.05），體質指數差異無統計學意義（P＞0.05）；兩組的日胰島素用量、日血糖波動情況差異無統計學意義（P＞0.05）；實驗組較對照組的治療費用低，低血糖例數多（P＜0.05），但達標所需時間長（P＜0.05）。結論門鼕胰島素聯閤甘精胰島素治療的低血糖髮生率高、達標時間長，但費用低，適用于基層醫院及經濟睏難的患者，值得推廣。
목적：탐토문동이도소연합감정이도소치료2형당뇨병적료효우세。방법선취2012년1월～2014년6월주원적68례2형당뇨병환자，수궤분위문동이도소연합감정이도소조（실험조）화이도소빙조（대조조），균위34례，량조균접수정규적당뇨병음식、운동지도급기타교육，생활작식시간급치료규률。실험조적소유환자균여이문동이도소（조、중、만찬전，즉각피하주사，낙화예）+감정이도소（만수전，피하주사，래득시）치료；대조조적소유환자균여이이도소빙지속피하주사문동이도소，량조환자균관찰매일공복혈당、3찬찬후2h혈당、만10시혈당、공복C태、공복정분매、공복지방매、일혈당파동정황、일이도소용량、저혈당례수、체질지수、치료체표시간급치료비용。결과각조치료전후적혈당공제정황、공복C태、공복정분매、공복지방매저사지표차이균유통계학의의（P＜0.05），체질지수차이무통계학의의（P＞0.05）；량조적일이도소용량、일혈당파동정황차이무통계학의의（P＞0.05）；실험조교대조조적치료비용저，저혈당례수다（P＜0.05），단체표소수시간장（P＜0.05）。결론문동이도소연합감정이도소치료적저혈당발생솔고、체표시간장，단비용저，괄용우기층의원급경제곤난적환자，치득추엄。
Objective To explore joint glargine insulin aspart treatment of type 2 diabetes treatment benefit. Methods Select from January 2012 to June 2014 68 hospitalized patients with type 2 diabetes in hospitalized patients were randomly divided into joint glargine insulin aspart group(experimental group)and insulin pump (control group) were 34 cases,two group were to receive formal diabetic diet,exercise instruction and other educational,lifestyle and treatment time rule.All patients in the experimental group were to be insulin aspart(early,before the dinner,immediate subcutaneous injection,aspart)+glargine(before sleep,subcutaneous,Lantus)treatment;all patients in the control group were to be continuous subcutaneous insulin aspart insulin pump,patients were observed dally fasting blood glucose,blood glucose 2 hours after a meal 3,10 pm glucose,fasting C-peptide,fasting blood amylase,lipase fasting,dally blood sugar fluctuations,insulin dosage dally,the number of cases of low blood sugar,body mass index,the standard treatment time and cost of treatment. Results Each group before and after treatment of blood glucose control,fasting C peptide,amylase,lipase on an empty stomach on an empty stomach these indicators were statistically significant (P < 0.05),body mass index had no statistical difference(P > 0.05);Two groups of day of insulin,blood sugar volatility no statistical difference(P > 0.05);The experimental group was lower than those of control group in treatment costs,low blood sugar more than the number of cases(P < 0.05),but long time needed for standard(P<0.05). Conclusion Joint insulin aspart insulin glargine high incidence of hypoglycemia,a long time standard,but low cost,suitable for primary hospital patients and difficult economy,it is worth promoting.
