中华医院感染学杂志
中華醫院感染學雜誌
중화의원감염학잡지
Chinese Journal of Nosocomiology
2015年
9期
1974-1975,1978
,共3页
尿路感染%粪肠球菌%屎肠球菌%耐药性
尿路感染%糞腸毬菌%屎腸毬菌%耐藥性
뇨로감염%분장구균%시장구균%내약성
Urinary tract infection%Enterococcus f aecalis%Enterococcus feces%Drug resistance
目的：探讨医院尿路感染患者中段尿中粪肠球菌及屎肠球菌的耐药性，为临床治疗粪肠球菌及屎肠球菌尿路感染提供依据。方法选取2010年3月－2013年3月收治的500例医院尿路感染患者，共分离出粪肠球菌126株及屎肠球菌85株，分析粪肠球菌、屎肠球菌的耐药性。结果粪肠球菌对四环素、红霉素、高浓度庆大霉素、高浓度链霉素的耐药率分别为77．78％、67．46％、37．30％、32．54％，对替考拉宁、万古霉素、替加环素的耐药率均为0；屎肠球菌对红霉素、青霉素G、氨苄西林、环丙沙星、莫西沙星等抗菌药物的耐药率＞90．0％，对替考拉宁、万古霉素、替加环素的耐药率均为0；126株粪肠球菌中产酶6株，产酶率为4．76％；85株屎肠球菌中产酶11株，产酶率为12．94％，两组比较差异有统计学意义（ P＜0．05）。结论粪肠球菌及屎肠球菌对抗菌药物的耐药性具有较大差异，多药耐药肠球菌的出现也为临床的治疗带来很大难度；对于肠球菌属感染患者的治疗需要重视对菌株的培养以及耐药性分析，减少抗菌药物的盲目使用，以降低耐药菌株的产生，提高治疗效果。
目的：探討醫院尿路感染患者中段尿中糞腸毬菌及屎腸毬菌的耐藥性，為臨床治療糞腸毬菌及屎腸毬菌尿路感染提供依據。方法選取2010年3月－2013年3月收治的500例醫院尿路感染患者，共分離齣糞腸毬菌126株及屎腸毬菌85株，分析糞腸毬菌、屎腸毬菌的耐藥性。結果糞腸毬菌對四環素、紅黴素、高濃度慶大黴素、高濃度鏈黴素的耐藥率分彆為77．78％、67．46％、37．30％、32．54％，對替攷拉寧、萬古黴素、替加環素的耐藥率均為0；屎腸毬菌對紅黴素、青黴素G、氨芐西林、環丙沙星、莫西沙星等抗菌藥物的耐藥率＞90．0％，對替攷拉寧、萬古黴素、替加環素的耐藥率均為0；126株糞腸毬菌中產酶6株，產酶率為4．76％；85株屎腸毬菌中產酶11株，產酶率為12．94％，兩組比較差異有統計學意義（ P＜0．05）。結論糞腸毬菌及屎腸毬菌對抗菌藥物的耐藥性具有較大差異，多藥耐藥腸毬菌的齣現也為臨床的治療帶來很大難度；對于腸毬菌屬感染患者的治療需要重視對菌株的培養以及耐藥性分析，減少抗菌藥物的盲目使用，以降低耐藥菌株的產生，提高治療效果。
목적：탐토의원뇨로감염환자중단뇨중분장구균급시장구균적내약성，위림상치료분장구균급시장구균뇨로감염제공의거。방법선취2010년3월－2013년3월수치적500례의원뇨로감염환자，공분리출분장구균126주급시장구균85주，분석분장구균、시장구균적내약성。결과분장구균대사배소、홍매소、고농도경대매소、고농도련매소적내약솔분별위77．78％、67．46％、37．30％、32．54％，대체고랍저、만고매소、체가배소적내약솔균위0；시장구균대홍매소、청매소G、안변서림、배병사성、막서사성등항균약물적내약솔＞90．0％，대체고랍저、만고매소、체가배소적내약솔균위0；126주분장구균중산매6주，산매솔위4．76％；85주시장구균중산매11주，산매솔위12．94％，량조비교차이유통계학의의（ P＜0．05）。결론분장구균급시장구균대항균약물적내약성구유교대차이，다약내약장구균적출현야위림상적치료대래흔대난도；대우장구균속감염환자적치료수요중시대균주적배양이급내약성분석，감소항균약물적맹목사용，이강저내약균주적산생，제고치료효과。
OBJECTIVE To investigate the drug resistance of Enterococcus f aecalis and Enterococcus f eces isolated from midstream urine specimens of the patients with urinary tract infections so as to provide guidance for clinical treatment of the urinary tract infections caused by the E .f aecalis and E .f eces .METHODS A total of 500 patients with urinary tract infections who were treated in the hospital from Mar 2010 to Mar 2013 were enrolled in the study ,totally 126 strains of E .f aecalis and 85 strains of E .feces were isolated ,and the drug resistance of the E . f aecalis and E .f eces was analyzed .RESULTS The drug resistance rates of the E .f aecalis to tetracycline ,erythro‐mycin ,high concentration gentamicin ,and high concentration streptomycin were 77 .78% ,67 .46% ,37 .30% , and 32 .54% ,respectively ;the drug resistance rates to teicoplanin ,vancomycin ,and tigecycline were 0 .The drug resistance rates of the E .feces to erythromycin ,penicillin G ,ampicillin ,ciprofloxacin ,and moxifloxacin were more than 90 .0% ;the drug resistance rates to teicoplanin ,vancomycin ,and tigecycline were 0 .Of the 126 strains of E .f aecalis ,6 strains produced enzymes ,with the enzyme‐producing rate of 4 .76% ,and 11 of 85 E .feces strains produced enzymes ,with the enzyme‐producing rate of 12 .94% ,there was significant difference between the two groups (P<0 .05) .CONCLUSIONS The E .f aecalis and E .feces vary significantly in the drug resistance , and the emergence of multidrug‐resistant Enterococci strains has challenged the clinical treatment .It is necessary to pay great attention to the culture of strains and analysis of drug resistance for the patients with Enterococcus spp infections and decrease the abuse of antibiotics so as to reduce the drug‐resistant strains and improve the therapeu‐tic effect .
