CAJ | 학술논문

目的：探讨幽门螺杆菌感染与自身免疫性甲状腺炎的相关性，为自身免疫性甲状腺炎的相关治疗提供参考。方法选取2011年7月－2013年7月收治的125例自身免疫性甲状腺炎患者为试验组，另选取125名健康人群作为对照组；运用免疫酶法分别对两组进行甲状腺球蛋白抗体（TGAb）和抗甲状腺过氧化物酶抗体（TPOAb）的测定，并通过ELISA法对幽门螺杆菌IgG抗体和IgA抗体进行检测；根据检测结果，在幽门螺杆菌IgG抗体阳性的甲状腺炎患者中随机抽选50例患者并将其等分为两组，治疗组予以抗幽门螺杆菌治疗，观察组不予以抗幽门螺杆菌治疗，在完成治疗5个月后，再测定其TGAb和TPOAb滴度并与其治疗前数据进行对比。结果试验组幽门螺杆菌感染阳性率、Ig G阳性率、Ig A阳性率分别为78．4％、66．4％、69．6％，对照组分别为41．6％、32．8％、39．2％，两组比较差异均有统计学意义（P＜0．05）；治疗组在进行抗幽门螺杆菌治疗后，其TGAb和TPOAb的滴度对比治疗前均有明显下降（P＜0．05），而观察组则保持不变。结论幽门螺杆菌感染与自身免疫性甲状腺炎相关，抗幽门螺杆菌治疗是治疗自身免疫性甲状腺炎的有效方法之一。
목적：탐토유문라간균감염여자신면역성갑상선염적상관성，위자신면역성갑상선염적상관치료제공삼고。방법선취2011년7월－2013년7월수치적125례자신면역성갑상선염환자위시험조，령선취125명건강인군작위대조조；운용면역매법분별대량조진행갑상선구단백항체（TGAb）화항갑상선과양화물매항체（TPOAb）적측정，병통과ELISA법대유문라간균IgG항체화IgA항체진행검측；근거검측결과，재유문라간균IgG항체양성적갑상선염환자중수궤추선50례환자병장기등분위량조，치료조여이항유문라간균치료，관찰조불여이항유문라간균치료，재완성치료5개월후，재측정기TGAb화TPOAb적도병여기치료전수거진행대비。결과시험조유문라간균감염양성솔、Ig G양성솔、Ig A양성솔분별위78．4％、66．4％、69．6％，대조조분별위41．6％、32．8％、39．2％，량조비교차이균유통계학의의（P＜0．05）；치료조재진행항유문라간균치료후，기TGAb화TPOAb적적도대비치료전균유명현하강（P＜0．05），이관찰조칙보지불변。결론유문라간균감염여자신면역성갑상선염상관，항유문라간균치료시치료자신면역성갑상선염적유효방법지일。
OBJECTIVE To explore the correlation between the Helicobacter pylori infections and the autoimmune thyroiditis so as to provide guidance for treatment of the autoimmune thyroiditis .METHODS A total of 125 patients with autoimmune thyroiditis who were treated from Jul 2011 to Jul 2013 were chosen as the experimental group , and 125 healthy people were assigned as the control group .The thyroglobulin antibody (TGAb) and anti‐thyroid peroxidase antibodies (TPOAb) were determined by means of immune enzymatic method;the IgG and IgA anti‐bodies of the H .pylori were detected by using ELISA .Totally 50 thyroiditis patients who were tested positive for IgG were randomly extracted and evenly divided into two groups :the treatment group was treated with the anti‐H .pylori therapy ,while the observation group was not given the anti‐H .pylori therapy ,and the TGAb and TPOAb titers were measured after the treatment for 5 months and were compared with those before the treatment . RESULTS The positive rate of H .pylori infection was 78 .4% in the experimental group ,41 .6% in the control group;the positive rate of IgG was 66 .4% in the experimental group ,32 .8% in the control group;the positive rate of IgA was 69 .6% in the experimental group ,39 .2% in the control group ,there was significant difference between the two groups (P<0 .05) .The TGAb and TPOAb titers of the treatment group were significantly re‐duced after the anti‐H .pylori therapy as compared with those before the treatment (P<0 .05) ,while they re‐mained unchanged in the observation group .CONCLUSION The H .pylori infection is associated with the autoim‐mune thyroiditis ,and the anti‐H .pylori therapy is an effective way to treat the autoimmune thyroiditis .