CAJ | 학술논문

目的：探讨哌拉西林／舒巴坦联合盐酸氨溴索治疗2型糖尿病肺部感染患者的疗效，以提高临床治疗水平。方法2011年6月－2014年6月98例2型糖尿病肺部感染患者随机分为观察组和对照组，每组各49例，所有患者均注射胰岛素控制血糖和常规对症治疗，并采用抗菌药物哌拉西林／舒巴坦静脉滴注治疗，观察组在此基础上给予盐酸氨溴索片治疗，对照组在此基础上给予盐酸溴己新片治疗，对比两组患者的治疗效果、症状改善起效时间和不良反应发生率。结果观察组患者治疗总有效率为91．8％，显著优于对照组的69．4％，差异有统计学意义（P＜0．01）；观察组患者的发热、咳嗽、咳痰症状改善时间及住院时间显著低于对照组，差异有统计学意义（ P＜0．01）；患者不良反应发生率观察组为10．2％、对照组为12．2％，差异无统计学意义。结论哌拉西林／舒巴坦联合盐酸氨溴索治疗2型糖尿病肺部感染，能提升治疗有效率、缩短症状改善时间，且不良反应小，值得临床推广。
목적：탐토고랍서림／서파탄연합염산안추색치료2형당뇨병폐부감염환자적료효，이제고림상치료수평。방법2011년6월－2014년6월98례2형당뇨병폐부감염환자수궤분위관찰조화대조조，매조각49례，소유환자균주사이도소공제혈당화상규대증치료，병채용항균약물고랍서림／서파탄정맥적주치료，관찰조재차기출상급여염산안추색편치료，대조조재차기출상급여염산추기신편치료，대비량조환자적치료효과、증상개선기효시간화불량반응발생솔。결과관찰조환자치료총유효솔위91．8％，현저우우대조조적69．4％，차이유통계학의의（P＜0．01）；관찰조환자적발열、해수、해담증상개선시간급주원시간현저저우대조조，차이유통계학의의（ P＜0．01）；환자불량반응발생솔관찰조위10．2％、대조조위12．2％，차이무통계학의의。결론고랍서림／서파탄연합염산안추색치료2형당뇨병폐부감염，능제승치료유효솔、축단증상개선시간，차불량반응소，치득림상추엄。
OBJECTIVE To explore the efficacy of piperacillin‐tazobactam combined with ambroxol hydrochloride in treatment of the type 2 diabetic mellitus patients with pulmonary infections so as to improve the clinical treatment . METHODS A total of 98 type 2 diabetic mellitus patients with pulmonary infections who were treated in the hospi‐tal from Jun 2011 to Jun 2014 were enrolled in the study and randomly divided into the observation group and the control group ,with 49 cases in each .All the patients were injected with insulin to control the blood glucose ,re‐ceived the conventional symptomatic treatment ,and were given the intravenous injection of piperacillin‐tazobac‐tam ,the observation group was treated with additional ambroxol hydrochloride tablet ,while the control group was given the additional bromhexine hydrochloride tablet ;the therapeutic effect ,onset time of improvement of symp‐toms ,and incidence of adverse reactions were observed and compared between the two groups .RESULTS The total effective rate of treatment of the observation group was 91 .8% ,significantly higher than 69 .4% of the control group(P<0 .01) .The time of improvement of symptoms such as fever and cough and the length of hospital stay of the observation group were significantly shorter than those of the control group(P<0 .01) .The incidence of ad‐verse reactions was 10 .2% in the observation group ,12 .2% in the control group ,and there was no significant difference .CONCLUSION As is used for the treatment of the type 2 diabetic mellitus patients with pulmonary in‐fections ,piperacillin‐tazobactam combined with ambroxol hydrochloride can raise the effective rate of treatment and shorten the time of improvement of symptoms ,with the incidence of adverse reactions low ,and it is worthy to be promoted in the hospital .