CAJ | 학술논문

脑缺血诱发的炎症级联反应会加重神经组织损伤并破坏血脑屏障，而缺血后血管发生可改善神经功能。抑制卒中后炎症反应、促进血管发生和保护血脑屏障可减轻神经组织损伤并促进神经功能恢复。单核细胞趋化蛋白1诱导蛋白可通过降解促炎性细胞因子 mRNA 从而抑制炎症信号通路，其特有的生物学特性也提示其在脑缺血中具有潜在的保护效应。文章重点讨论单核细胞趋化蛋白1诱导蛋白在脑缺血中的作用。
뇌결혈유발적염증급련반응회가중신경조직손상병파배혈뇌병장，이결혈후혈관발생가개선신경공능。억제졸중후염증반응、촉진혈관발생화보호혈뇌병장가감경신경조직손상병촉진신경공능회복。단핵세포추화단백1유도단백가통과강해촉염성세포인자 mRNA 종이억제염증신호통로，기특유적생물학특성야제시기재뇌결혈중구유잠재적보호효응。문장중점토론단핵세포추화단백1유도단백재뇌결혈중적작용。
Cerebral ischemia-induced inflammatory cascade reaction may aggravate nerve tissue damage and destroy blood-braln barrier, and angiogenesis after ischemia can improve nerve function. Inhibiting inflammatory response after stroke, promoting angiogenesis and protecting blood-braln may reduce nerve tissue damage and promote recovery of neurological function. Monocyte chemotactic protein 1-induced protein inhibits inflammatory signaling pathways through degradating proinflammatory cytokine mRNA. Its unique biological characteristics also suggest that it has the potential protective effect in cerebral ischemia. This article focuses on the roles of monocyte chemotactic protein 1-induced protein in cerebral ischemia.