CAJ | 학술논문

目的：分析万古霉素鞘内注射与持续腰大池引流对高血压脑出血术后颅内感染患者的治疗疗效，为临床诊治提供参考。方法选择2011－2013年巴州人民医院收治的76例高血压脑出血术后颅内感染患者，将其随机分成观察组和对照组，各38例，两组患者均使用万古霉素鞘内注射，观察组在万古霉素鞘内注射基础上给予腰大池持续引流，引流时间为1～2周，比较两组患者的感染控制及临床疗效。结果两组患者脑脊液成分在治疗前比较差异无统计学意义；治疗后脑脊液中白细胞、蛋白质含量均有显著降低，葡萄糖含量有显著升高，两组患者治疗前后脑脊液成分比较差异有统计学意义（ P＜0．05）；治疗后的总有效率观察组为92．11％、对照组为76．32％，两组患者的疗效差异有统计学意义（ P＜0．05）。结论持续腰大池引流联合万古霉素鞘内注射治疗高血压脑出血术后颅内感染具有显著的疗效，能明显改善患者的感染症状，适合在临床上推广应用。
목적：분석만고매소초내주사여지속요대지인류대고혈압뇌출혈술후로내감염환자적치료료효，위림상진치제공삼고。방법선택2011－2013년파주인민의원수치적76례고혈압뇌출혈술후로내감염환자，장기수궤분성관찰조화대조조，각38례，량조환자균사용만고매소초내주사，관찰조재만고매소초내주사기출상급여요대지지속인류，인류시간위1～2주，비교량조환자적감염공제급림상료효。결과량조환자뇌척액성분재치료전비교차이무통계학의의；치료후뇌척액중백세포、단백질함량균유현저강저，포도당함량유현저승고，량조환자치료전후뇌척액성분비교차이유통계학의의（ P＜0．05）；치료후적총유효솔관찰조위92．11％、대조조위76．32％，량조환자적료효차이유통계학의의（ P＜0．05）。결론지속요대지인류연합만고매소초내주사치료고혈압뇌출혈술후로내감염구유현저적료효，능명현개선환자적감염증상，괄합재림상상추엄응용。
OBJECTIVE To evaluate the effect of intrathecal injection of vancomycin combined with continuous lum‐bar drainage on treatment of the hypertensive intracerebral hemorrhage patients with postoperative intracranial in‐fections so as to provide guidance for clinical diagnosis and treatment .METHODS A total of 76 hypertensive intrac‐erebral hemorrhage patients with postoperative intracranial infections who were treated in the Xinjiang Korla Peo‐ple′s Hospital from 2011 to 2013 were enrolled in the study and randomly divided into the observation group and the control group ,with 38 cases in each .Both groups were treated with intrathecal injection of vancomycin ,while the observation group was given additional continuous lumbar drainage on the basis of the intrathecal injection of vancomycin ,with the drainage duration of 1 to 2 weeks .The clinical effect on control of infections was observed and compared between the two groups of patients .RESULTS There was no significant difference in the composition of cerebrospinal fluid between the two groups before the treatment ;the contents of white blood cells and protein in the cerebrospinal fluid were significantly reduced after the treatment ,while the content of glucose was significantly elevated (P<0 .05) .The total effective rate of treatment was 92 .11% in the observation group ,76 .32% in the control group , and there was significant difference in the efficacy between the two groups ( P < 0 .05 ) . CONCLUSION Continuous lumbar drainage combined with intrathecal injection of vancomycin can achieve signifi‐cant effect on treatment of the hypertensive intracerebral hemorrhage patients with postoperative intracranial infec‐tions and remarkably improve the symptoms of the patients with infections ,and it is worthy to be promoted in the hospital .